Subungual melanoma (SUM) is a subtype of acral melanoma. Its incidence in dark phototypes, Hispanics and Asians, is around 20% and accounts for 50% of acral melanomas. It is an infrequent subtype in Caucasians representing only 3%. Subungual melanoma arises from dormant melanocytes in the nail matrix and exceptionally from melanocytes in the nail bed. In its initial phases of radial growth, it presents as longitudinal melanonychia. The differential diagnoses are melanocytic activation (racial, traumatic), nail matrix nevi, and lentigos. Prognosis depends on Breslow depth at diagnosis. For in situ melanoma, treatment consists of conservative surgical removal of the nail unit with 5 mm margins.
Desarrollo infantil temprano y discapacidad 17 viable, confiable y con valores ideales de especificidad y sensibilidad superiores a 0.70. Para conocer estos valores es necesario que las pruebas sean sometidas a un proceso de validación concurrente que busque conocer la medida en la que coinciden los resultados de dicha prueba, con las evaluaciones diagnósticas consideradas "estándar de oro" o con aquellas habitualmente utilizadas y consideradas de referencia. 10 Se realizó una revisión sistemática de las pruebas de tamizaje de problemas en el desarrollo infantil para niños menores de cinco años, validadas en América (de 1988 a 2012), con los siguientes resultados: 11
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