Two new tetrahydroanthraquinone derivatives, altersolanol Q (1) and 10methylaltersolanol Q (2), and the new dimer alterporriol X (3), together with 13 known analogues were isolated from white bean solid culture media of the endophytic fungus, Stemphylium globuliferum, obtained from the Egyptian mangrove plant Avicennia marina.The present study resulted in the production of a large diversity of secondary metabolites including new derivatives. Their structures were elucidated using one-and two-dimensional NMR spectroscopy as well as HRESIMS. The absolute configurations of the new compounds 1-3 were determined by TDDFT-ECD calculations or by comparing ECD data with those of known analogues. Compounds 1-3 were tested against the L5178Y mouse lymphoma cell line but proved to be inactive in contrast to some of the known compounds such as altersolanol A (6) that were likewise isolated in this study.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.