This work includes a synthesis of 3-acetyl-7-hydroxy-2H-chromen-2-one (1) through the reaction of 2,4-dihydroxybenzaldehyde with ethyl acetoacetate, then reacted with 4-(dimethylamino) benzaldehyde to produce Coumarinyl Chalcone (2). And cyclization of Coumarinyl Chalcones (2) with malononitrile in the presence of ammonium acetate to produce 2-amino-4-(4-(dimethylamino) phenyl)-6-(7-hydroxy-2-oxo-2H-chromen-3-yl) nicotinonitrile (3). Prepared compounds were diagnosed through melting point, TLC, FT-IR Spectroscopy analysis and 1H-NMR. Quantum chemical parameters like highest occupied molecular orbital energy, lowest unoccupied molecular orbital energy (EHOMO while ELUMO), while dipole moment (μ) was interpretation.
This work included synthesis of several new pyridine derivatives (3a-c) by cyclization of Coumarinyl Chalcones (2a-c) with malononitrile in presence of ammonium acetate. Prepared compounds were diagnosed using Melting point, TLC, FT-IR spectroscopy and 1H-NMR. The synthesized pyridines (3a-c) were screnned for their antibacterial and antifungal activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella sp., and Candida albicans. Respectively by diffusion method compounds 3a, 3b and 3c showed good antibacterial activity and by comparison with the medicine Ampicillin. Compounds 3a, 3b and 3c showed moderate antifungal activity compared to the standard drug fluconazole.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.