Objetivo: Avaliar o perfil clínico e bioquímico de pacientes com e sem HPTS. Metodologia: Estudo transversal e analítico realizado com 93 pacientes com DRC em HD. Os pacientes foram alocados em dois grupos: sem HPTS (Paratormônio: < 300pg/mL) e com HPTS (Paratormônio: ≥ 300pg/mL). Foram verificados os dados socioeconômicos por meio de questionário semiestruturado. Os dados bioquímicos e antropométricos foram obtidos por meio do prontuário de cada paciente. Também foram coletadas informações quanto ao tempo de HD, tabagismo, diabetes mellitus, hipertensão arterial sistêmica, cardiopatias, atividade física e a razão triglicerídeo/HDL-Colesterol. Resultados: O gênero feminino apresentou-se prevalente no grupo com HPTS (59,09%, p=0,017). Nos pacientes que não apresentavam HPTS foi detectado maior presença de diabetes mellitus (77,27%, p=0,021). Os pacientes com HPTS diferiram dos pacientes sem HPTS para o hematócrito (p=0,0457), creatinina (p=0,0303) e a fosfatase alcalina (p=0,0011). Conclusão: Encontramos diferença ao comparar os grupos quanto aos níveis de hematócrito, creatinina, fósforo e fosfatase alcalina, resultados que podem implicar no estado clínico de indivíduos com HPTS. Essas análises poderão direcionar condutas e estratégias específicas para o acompanhamento da doença e proposta adequada de tratamento, buscando a melhora do quadro clínico e qualidade de vida. DESCRITORES: Hiperparatireoidismo Secundário. Insuficiência Renal Crônica. Diálise Renal.
Introduction: Chronic kidney disease (CKD) is a global public health problem, which implies poor health and high risk of cardiovascular disease contributing to high mortality rates, whichhas been associated with high levels of alkaline phosphatase (AF) in this public. The aim of this study was to compare clinical and biochemical parameters in relation to alkaline phosphatase levels of chronic renal patients on hemodialysis. Methods: Cross-sectional and analytical study, performed in 93 male and female patients, aged 18 years or older, from a hemodialysis center in the city of Belém, Pará. Data collection included interviews through a semi-structured questionnaire and consultation of medical records. Descriptive statistics consisted of mean, standard deviation, median, interquartile range, relative and absolute frequency. For alkaline phosphatase analysis, the interquartile range of 120 U/L was used. Results: Of the 93 patients, 58 were men with a mean age of 54.5 ± 4.5 years. The sample was divided into two groups: the first, with low alkaline phosphatase - less than 120 U/L (n= 50; 82.24 ± 21.67); and the second, with high alkaline phosphatase - greater than or equal to 120 U/L (n= 43; 288.82 ± 300.05). After analyzing the clinical and biochemical profile of each group, we found a statistical difference in the values of parathyroid hormone and hemoglobin, in which the group with high alkaline phosphatase obtained higher parathyroid hormone levels and lower hemoglobin values. Considerable prevalence of elevated phosphatase was observed in chronic renal patients on hemodialysis. Conclusion: The study identified high parathyroid hormone and lower hemoglobin in patients with high alkaline phosphatase. We emphasize the importance of monitoring and correcting AF levels, when possible.
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