Ventriculitis are a complication of meningitis (community-acquired or nosocomial) or another central nervous system infections as brain abscess. They are associated to a different spectrum of microorganisms from resistant gram-negative bacilli to staphylococci that can lead serious illness with high mortality. Difficult-to-treat resistance Gram-negative bacilli may increase to 20% deaths respect susceptible isolates of the same bacteria. We present the first report of a clinical cured case of difficult-to-treat resistant Pseudomonas aeruginosa (DTR-P) ventriculitis in which cefiderocol penetration into the central nervous system (CNS) has been confirmed in blood and cerebrospinal fluid (CSF). Cefiderocol might be considered for difficult-to-treat CNS infections in view of the recent new cases published together our one.
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