Case summary A 3-year-old neutered male domestic shorthair cat developed pancytopenia 6 months after starting phenobarbital for treatment of recurrent seizures. The cat was switched from phenobarbital to levetiracetam and complete resolution of the pancytopenia was documented within 10 weeks, consistent with phenobarbital-induced pancytopenia. Relevance and novel information While phenobarbital is frequently used as the first-line treatment for seizures in cats, phenobarbital-induced feline pancytopenia has not been documented in the veterinary literature before. Based on this case, regular monitoring of the complete blood count in cats receiving long-term phenobarbital treatment should be considered. In cases of persistent or severe haematological abnormalities, further investigations are required and treatment discontinuation may be needed in the absence of other causes of pancytopenia.
Case summary A 9-month-old entire male domestic longhair cat presented with a history of pathological fractures, chronic musculoskeletal pain and poor growth. Multiple facial and skeletal abnormalities were identified on physical examination and advanced imaging (CT and radiographs). A variant in CTSK was identified in the affected cat following whole-exome sequencing (WES). The cat was managed symptomatically with diet, environmental modifications and analgesia. Relevance and novel information This is the first report of a cat with a similar clinical presentation and genetic variant to the hereditary human genetic disorder pyknodysostosis. In this case, WES was performed, which often facilitates the diagnosis of various hereditary disorders (ie, a conceptual framework for practicing feline genomic medicine). Despite the severe skeletal and appendicular abnormalities described, the cat was alive more than 2 years after its initial presentation.
Primary gastric lymphoma is a well-characterised disease in humans, but is poorly characterised in cats. This study retrospectively describes the presentation, diagnosis, treatment and outcome of cats with primary gastric lymphoma in a UK referral hospital. Medical records of cats diagnosed with primary gastric lymphoma, without ultrasonographic involvement of the intestinal tract, between 2009 and 2020 were reviewed. A total of 13 cats met the inclusion criteria. All cases were of large cell lymphoma. Cytology alone was diagnostic in nearly all cases (10/11). At diagnosis six cats were euthanised. The remaining seven cats were treated with a multiagent chemotherapy protocol (5/7) or a combination of prednisolone and chlorambucil (2/7). Median overall survival time was 300 days (ranging from 30–1980 days). The two cats treated with prednisolone and chlorambucil survived for 300 and 480 days respectively. This study raises awareness of feline primary gastric lymphoma for veterinary surgeons in clinical practice. Although an uncommon disease presentation, primary gastric lymphoma has unique characteristics that may differ from the high-grade intestinal form. Further studies are needed to evaluate the optimum therapeutic approach.
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