The aim of this study was to analyze whether the coronavirus disease 2019 (COVID-19) vaccine reduces mortality in patients with moderate or severe COVID-19 disease requiring oxygen therapy. A retrospective cohort study, with data from 148 hospitals in both Spain (111 hospitals) and Argentina (37 hospitals), was conducted.We evaluated hospitalized patients for COVID-19 older than 18 years with oxygen requirements. Vaccine protection against death was assessed through a multivariable logistic regression and propensity score matching. We also performed a
Background
Non‐attendance to scheduled medical appointments in outpatient clinics is a problem that affects patient health and health‐care systems.
Objective
Evaluate association of non‐attendance to scheduled appointments in outpatient clinics and Emergency Department (ED) visits, hospitalizations and mortality.
Methods
Retrospective cohort study of outpatients enrolled in 2015 to 2016 in the Hospital Italiano de Buenos Aires HMO with over five scheduled appointments. Individual non‐attendance proportion was obtained by dividing missed over scheduled appointment numbers in the 365 days prior to index date. Outcomes were evaluated with a Cox proportional‐hazards or Fine and Gray model for competing risks. We adjusted by several variables.
Results
Sixty‐five thousand two hundred sixty‐five adults were included. Mean age was 63.6 years (SD 18.16), 29.9% male. Outpatients had average 10.18 (SD 5.59) appointments. Non‐attendance the year before the index appointment had a median of 20%. A 10% increase in non‐attendance was significantly associated with ED visits (asHR 1.19; 95%CI 1.08‐1.32, P < .001) and all‐cause mortality (aHR 7.57; 95%CI 4.88‐11.73, P < .001). In the matched subcohort analysis we observed a crude significant association of non‐attendance with ED visits (P < .001) and all‐cause mortality (P < .001).
Discussion
Our findings show non‐attendance could be a marker of health events that lead to emergency department evaluations and/or death.
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