Spirulina supplementation induced a significant increase in exercise performance, fat oxidation, and GSH concentration and attenuated the exercise-induced increase in lipid peroxidation.

Parkinson’s disease (PD) is a progressive movement disorder caused by the death of dopamine-producing cells in the midbrain. PD is the most prevalent movement disorder of the central nervous system and affects more than 6.3 million people in the world. The changes in the motor functions of patients are not easy to be clearly and on-time observed by the clinicians and to make the most well-informed decisions for the treatment. The aim of this paper is the monitoring PD by designing, developing, and evaluating a prototype mobile App using a pressure pen, which collects quantitative and objective information about PD patients, thus allowing clinicians to understand better and make assumptions about the severity and the stage of Parkinson’s disease. This study presents a dynamic spiral test that can only be performed with tablet and pen pressure. Furthermore, the handwriting samples by PD patients and healthy controls individuals are collected by a computerized system, and the measurements of Spiral Deviation, Total Time, and Pen Pressure are processed. The results showed an accurate evaluation of the stage of Parkinson’s disease. Thus, the clinician may use the proposed PD telemonitoring system as a screening test, storing the history of all the patient’s measurements.

In this survey, the issues of urban routing are analyzed, and critical considerations for smart and cost-effective delivery services are highlighted. Smart cities require intelligent services and solutions to address their routing issues. This article gives a brief description of current services that either apply classical methods or services that employ machine learning approaches. Furthermore, a comparison of the most promising research options in regard to VRP is provided. Finally, an initial design of a holistic scheme that would optimally combine several tools and approaches to serve the needs of different users with regard to the VRP is presented.

This work proposes an effective solution to the Vehicle Routing Problem, taking into account all phases of the delivery process. When compared to real-world data, the findings are encouraging and demonstrate the value of Machine Learning algorithms incorporated into the process. Several algorithms were combined along with a modified Hopfield network to deliver the optimal solution to a multiobjective issue on a platform capable of monitoring the various phases of the process. Additionally, a system providing viable insights and analytics in regard to the orders was developed. The results reveal a maximum distance saving of 25% and a maximum overall delivery time saving of 14%.

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