Single cobalt sites in mesoporous N-doped carbon matrix for selective catalytic hydrogenation of nitroarenes.

A wide variety of steric and electronic features can be incorporated into transition metal coordination complexes, offering the prospect of rationally-designed therapeutic agents with novel mechanisms of action. Here we compare the chemical reactivity and anticancer activity of organometallic Os II complexes [Os(h 6 -arene)(XY)Z]PF 6 where arene ¼ p-cymene or biphenyl, XY ¼ N,N 0 -chelated phenyliminopyridine or phenylazopyridine derivatives, and Z ¼ Cl or I. The X-ray crystal structure of [Os(h 6 -p-cym)(Impy-OHLike the azopyridine complexes we reported recently (Dalton Trans., 2011, 40, 10553-10562), some iminopyridine complexes are also potently active towards cancer cells (nanomolar IC 50 values). However we show that, unlike the azopyridine complexes, the iminopyridine complexes can undergo aquation, bind to the nucleobase guanine, and oxidize coenzyme nicotine adenine dinucleotide (NADH). We report the first detection of an Os-hydride adduct in aqueous solution by 1 H NMR (À4.2 ppm). Active iminopyridine complexes induced a dramatic increase in the levels of reactive oxygen species (ROS) in A549 lung cancer cells. The anticancer activity may therefore involve interference in the redox signalling pathways in cancer cells by a novel mechanism.

Lamiaceae is one of the largest families of aromatic plants and it is characterized by the presence of external glandular structures which produce essential oils highly valued in cosmetics and medicine. Plants of Lavandula latifolia, Mentha piperita, Salvia sclarea, Salvia lavandulifolia, Thymus capitatus, and Thymus mastichina were grown for one year. In order to evaluate the effects of drought stress, plants were subjected to two water treatments (100% ETo and 70% ETo, including the rainfall during the experimental period). At the end of the experiment, the biomass, the essential oil content, and leaf nutrients concentration were assessed for each water treatment and species studied. At the end of the experiment, L. latifolia, M. piperita and T. capitatus plants showed a significant fresh weight reduction under drought stress conditions whereas the other species studied remained unchanged. With respect to dry weight, only L. latifolia plants showed a reduction under water deficit conditions. As far as essential oil content was concerned, L. latifolia and S. sclarea plants had a reduction under water deficit conditions. Leaf nutrient concentration showed different trends between species considering the nutrient assessed. The economic viability of the growth of this species will be dependent on the benefits achieved which are related to yield production obtained and the price accorded for both raw material and the essential oil extracted.

Syste `mes Organise ´s Fluore ´s a `Finalite ´s The ´rapeutiques (SOFFT),