The deposition of layers of different polycations (synthetic or derived from natural, renewable resources) onto oppositely charged surfaces has been studied using ellipsometry and quartz crystal microbalance with dissipation monitoring (QCM-D). Information about the thickness of the deposited layers and their water content was ascertained. The adsorption of the different polycations onto negatively charged surfaces was found to be a complex process, which is influenced by the chemical nature of the polymer chains, ionic strength, polymer concentration and the addition of additives such as surfactants. The experimental picture shows a good agreement with theoretical calculations performed using the Self-Consistent Mean Field (SCF) approach. The results show that the electrostatically-driven deposition can be tuned by modifying the physico-chemical properties of the solutions and the chemical nature of the adsorbed polymer. This versatile approach is a big step forward in aiding the design of new polymers for many industrial applications and, in particular, the design of sustainable washing formulations for cosmetic applications.
In this study, new blends of PCL/PEC have been prepared in an easy manner by casting with the objective of obtaining new biomaterials to apply to tissue engineering and bone regeneration. The PCL/PEC blends obtained, together with neat polymer blends, were characterized by infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). This full characterization is the key to disentangle the miscibility, which means good compatibility, of the polymer blends used in this work. The addition of increasing amounts of PEC, has shown in the new biomaterials obtained, a remarkable improvement in relation with the mechanical properties (manageable materials) and above all, in terms of an increase in their hydrophilic character with respect to the PCL neat polymer. The improvement of all these properties is reflected in their biological properties. With these thoughts in mind, the blends obtained were tested through the assessment of several biological parameters such as cell viability, proliferation, and differentiation of both the MC3T3-E1 osteoblastic cell line and hMSCs to evaluate their cell response to different polymer membranes aimed at bone tissue regeneration. “In vitro” biocompatibility methods have been chosen rather than in vivo studies due to their lower cost, faster procedure time, and minimum ethical concerns, and because it was the first time that the biological effects of these blends were studied. The results show that the PCL/PEC blends obtained, with tunable properties in terms of hydrophilic character and hydrolytic degradation, may be regarded as good candidates to perform “in vivo” tests and check their real-life applicability for bone regeneration. The polymer acronym (the weight percentage in the sub index) is PCLx/PECy as noted in table one with the summary of compositions.
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