Ocimum is one of the most important genera of the Lamiaceae family. Several studies about basil and its popular use reveal many characteristics of the herb, including its use as antioxidant, anti-aging, antiinflammatory, anti-carcinogenic, anti-microbial, and cardiovascular agents, among others. In this paper, we evaluated genotoxic, oxidative, and anti-inflammatory parameters from the extract of Ocimum basilicum in different concentrations, using human leukocytes cultures exposed to challenging agents. Our results confirm that the O. basilicum extract acts as an antioxidant and effectively reverts or subjugates the effects of high oxidizing agents such as hydrogen peroxide. These actions are attributed to its composition, which is rich in polyphenols and flavonoids as well as compounds such as rosmarinic acid, all of which have well-known antioxidant activity. We also show that our basil extract presents anti-inflammatory properties, the mechanism of which is a composed interaction between the inhibition of pro-inflammatory mediator and the stimulation of anti-inflammatory cytokines. Although pharmacodynamics studies are necessary to evaluate the activities in vivo, our results demonstrated that basil could act as an antioxidant and anti-inflammatory and a possible alternative for medicinal treatment.
Uniterms:Ocimum basilicum/evaluation. Ocimum basilicum/genotoxic effects. Ocimum basilicum/ anti-inflammatory properties. Medicinal plants/study.
RESUMOEm muitos lugares ao redor do mundo as plantas medicinais ou parte delas são usadas de forma paliativa ou curativa para o tratamento de diversas enfermidades, devido a dificuldade ao acesso a tratamentos convencionais. Nesse contexto, preparações a base de Phyllanthus niruri, que é popularmente conhecida como "Quebra-Pedra" ou "Erva-Pombinha" tem sido muito usadas no tratamento de diversas enfermidades como hipertensão, diabetes, cálculos renais, entre outros. O presente estudo visou avaliar a capacidade anti-genotóxica do extrato hidroalcoólico de Phyllanthus niruri, através da análise fitoquímica e dosagem de compostos, avaliação de parâmetros genotoxicológicos e oxidativos. Os resultados mostram que o Phyllanthus niruri possui uma grande quantidade de compostos antioxidantes, tendo estes ação na proteção em nível de DNA, onde o extrato mostrou-se capaz de aumentar a viabilidade celular e de parâmetro oxidativos, mostrando ser capaz de diminuir a peroxidação lipídica.
AVALIAÇÃO DOS EFEITOS ANTI-GENOTÓXICOS DE Phyllanthus niruri (EUPHORBIACEAE) EM LEUCÓCITOS HUMANOS EXPOSTOS A AGENTE AGRESSOR ASSESSMENT OF ANTIGENOTOXIC EFFECTS OF Phyllanthus niruri (EUPHORBIACEAE) IN HUMAN LEUKOCYTE EXPOSED TO AGENT AGGRESSOR
ABSTRACTIn many places around the world medicinal plants or parts of them are used for palliative or curative method for the treatment of various diseases due to difficult access to conventional treatments. In this context, based preparations Phyllanthus niruri, which is popularly known as "Break-Stone" or "Yerba Pombinha" has been widely used in the treatment of various diseases such as hypertension, diabetes, kidney stones, among others. This study aimed to evaluate the antigenotoxic ability of hydroalcoholic Phyllanthus niruri extract by phytochemical analysis and dosage of compounds, evaluation genotoxicologic and oxidative parameters. The results show that Phyllanthus niruri has a large amount of antioxidant compounds having such action on DNA level protection, where the extract proved to be able to increase cell viability and oxidative parameter showing be able to decrease lipid peroxidation.
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