In 8 patients with complete heart block, cardiac and hemuodynammic functions were determined by methods based on cardiac catheterization. The data characterize the impairment in these functions in asymptomatic subjects and indicate, in addition, the further changes over the course of several years in the same subject, the deleterious effects associated with congestive heart failure, and the changes toward normal induced by isopropylnorepinephrine, a symaipathomiimetic amine known to stimulate the heart and increase ventricular rate in heart block.THE purpose of this report is to present data regarding cardiovascular hemodynamicg functions in patients with established complete heart block.Levinson et al.1 determined cardiovascular dynamics by cardiac catheterization in 5 patients with complete heart block, without congestive heart failure at any time, and reported the following lienodynamnic alterations from the normal: elevated systolic pressure in the right atrium, elevated systolic pressure in the right ventricle and pulmonary artery, increased pulse pressure in pulmonary and systemic arteries, increased stroke volume, and decreased cardiac output. The present study confirms these observations and reports additional information on the following cardiovaseular aspects of complete heart block: changes in cardiovascular dynamics in the same patient over the course of several years, comparison of hemodynamic functions when there is congestive heart failure with the hemodynamic status when heart failure is absent, the hemodynamic effects of isopropylnorepinephrine, a sympathomimetic amine known to increase the ventricular rate in complete heart block.2 Renal hemodynamic functions of 3 of the subjects are also reported.
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