O objetivo do presente estudo foi avaliar a capacidade do midazolam e do fentanil em reduzir da dose de indução do propofol e a qualidade de indução de cadelas pré-medicadas com acepromazina (0,03 mg/kg) e morfina (0,3 mg/kg). Trinta minutos após a administração da pré-medicação (T30) foram avaliadas a frequência cardíaca (FC) e respiratória (FR), pressão arterial sistólica (PAS), temperatura retal (TR). Em seguida, os cães foram aleatoriamente designados a receber um dos três tratamentos (n = 8): midazolam-propofol (grupo MP), fentanil-propofol (grupo FP) ou solução salina-propofol (grupo SP). Imediatamente após a administração do agente de co-indução, a anestesia foi induzida com propofol IV (2 mg/kg/minuto). A dose de propofol necessária para a intubação orotraqueal, a qualidade da indução e a ocorrência de efeitos indesejáveis foram registradas. Em T30, foi observado incremento sedativo nos grupos MP, FP e SP em relação ao momento basal (P < 0,05). Em T30, foi observada diminuição na FC, PAS e TR em relação ao basal (P < 0,05). Não houve diferença entre os grupos em relação aos escores de sedação, FC, FR, PAS, TR, dose de indução do propofol e qualidade de indução anestésica (P > 0,05). Foi observada apneia em quatro cães do grupo MP e em dois cães do grupo FP. Um cão do grupo MP apresentou rigidez muscular. Nas doses utilizadas, o midazolam e fentanil não foram capazes de reduzir a dose de indução do propofol em cães pré-medicados com acepromazina-morfina. A qualidade de indução anestésica foi excelente, com possível ocorrência de apneia e rigidez muscular. A associação acepromazina-morfina resulta em sedação de leve a moderada, e diminuição da FC, PAS e TR.

Background: Flexural deformities are anatomical deviations, in varying degrees, of one or more joints, and may have a congenital or acquired origin. Congenital contracture of the deep digital flexor tendon (DDFT) affects newborn calves and results in hyperflexion of the metacarpal-phalangeal joint, which in severe cases means that the animal must support its own weight on its fetlock joints. The aim of this study is to report the rapid and successful result of applying bilateral total tenotomy technique on a newborn bovine that had been diagnosed with severe bilateral DDFT contracture in the thoracic limbs.Case: A 3-week-old male bovine with a history of difficulty in maintaining a quadrupedal position was attended at the Veterinary Hospital of the Federal University of Tocantins. The animal had severe bilateral locomotor alterations in the thoracic members to the point that he walked on his fetlock joints. The physical examination revealed clinical parameters within the normal range. However, the locomotor system examination showed severe flexor deformity in the bilateral metacarpal-phalangeal joints, and the limbs were being supported on the dorsal face of the fetlock joints, which presented ulcerations, and was suggestive of a shortening of the DDFT. Based on the patient's history and clinical examination, as well as the severity of the tendon contractures, surgical treatment using the DDFT bilateral total tenotomy technique was decided upon. Postoperative treatment consisted of 2.5 mg/kg of enrofloxacin intramuscularly (IM), SID, for 5 days and 0.5 mg/kg meloxicam via IM, SID, for 3 days; as well as a dressing (cotton, medical bandage and a PVC mold) on the thoracic limbs to provide support and allow the animal to walk, until its complete recovery. One day after the surgery, the animal was able to walk with difficulty and some trembling; however, on the third day after the surgical procedure, it could stand up by itself, walk and graze normally. The surgical stitches were removed seven days after the operation, as the surgical wounds had healed adequately. The animal was followed-up for a one-month period after the total tenotomy, with no recurrence of any of the clinical signs, and the thoracic limbs had regained normal biomechanics.Discussion: Congenital flexural deformities are common in newborn calves of different breeds and their incidence is mainly in the thoracic limbs, especially in the carpal, distal interphalangeal and metacarpal-phalangeal joints as was reported in the animal in this study. The history and anamnesis of the animal, along with a thorough physical examination, in order to rule out any other congenital alterations, was extremely important in the diagnosis, and the classification of the severity of the deformity along with the choice of appropriate treatment in the present study. Although total tenotomy is rarely reported in the literature, and there are controversial results with calves, the surgical treatment was chosen in the present case due to the severity of the case. The DDFT bilateral total tenotomy surgical technique gave satisfactory results for the correction of severe bilateral flexor deformity in the thoracic limbs of the newborn crossbred calf. Complete recovery of the limb biomechanics was rapid, and there was no post-surgical complications, thus ensuring the animal could have a good and healthy life. Total DDFT tenotomy is considered a viable surgical procedure for calves with severe congenital flexor deformities; however, post-operative care is also important to ensure good final results.

This study aims to evaluate the influence of free omental graft without vascular microanastomosis (FOGWVA) on experimental skin healing in rabbits. Through celiotomy, a 9cm2 free omental fragment was collected in 36 rabbits, with subsequent production of a deep linear cutaneous wound in the dorsal midline measuring 3cm. In 18 animals from the omental group (OG), the omental fragment collected was fixed subcutaneously with six simple interrupted stitches using a 4-0 polyamide thread. In both treated and control (CG) groups, intradermal dermorrhaphy was performed with 4-0 polyamide thread. Experimental wounds were clinically evaluated every day. Each of the groups was divided into three subgroups of 6 animals each for histopathological evaluation on the 7th, 14th, and 28th days of postoperative. In the OG wounds, the increase in volume (omentum activation) stood out after the second postoperative day. Macroscopy showed an organic reaction to the graft on day 7, with a progressive reduction in addition to neovascularization towards the omental graft. The intense presence of mononuclear cells and collagen deposition on day 7 demonstrated an accelerated process of tissue remodeling and repair. The FOGWVA omental graft remained viable and positively influenced the cutaneous healing of the experimental wounds in rabbits.

Piometra é uma patologia infecciosa, potencialmente fatal, que acomete o endométrio de cadelas, caracterizada pelo acúmulo de pus no lúmen uterino. Em geral, esta patologia ocorre no período do diestro, devido à infecção bacteriana ascendente que encontra ambiente propício para sua multiplicação no endométrio que sofreu hiperplasia cística em decorrência do estímulo cumulativo e prolongado dos hormônios femininos. Normalmente, não possui predisposição racial e acomete mais animais de meia-idade e idosos, a partir do 4o ciclo estral. Animais jovens raramente apresentam esta patologia e, quando ocorre, geralmente está associada ao uso de progestágenos exógenos. O objetivo deste trabalho é relatar o caso de uma cadela, da raça Bulldog inglês, de 10 meses, que não fazia uso de progestágenos exógenos diagnosticada com piometra. A paciente foi atendida pelo Hospital Veterinário da Universidade Federal Rural do Rio de Janeiro com secreção vulvar muco-hemorrágica há 24 horas. De acordo com o tutor, a cadela havia apresentado o primeiro cio 13 dias antes do atendimento. No exame físico geral a paciente apresentou parâmetros clínicos dentro da normalidade, com exceção da temperatura (febre), frequência respiratória (taquipneia), frequência cardíaca (taquicardia), e do lactato sanguíneo (aumentado). Devido a presença de síndrome da resposta inflamatória sistêmica (taquipneia, taquicardia e febre) associado a possível foco infeccioso, solicitou-se hemograma e bioquímica sérica renal e hepática. No hemograma foi avaliado leucocitose neutrofílica, indicando processo inflamatório/infeccioso, na bioquímica sérica observou-se disfunção hepática. Realizou-se também ultrassonografia abdominal que avaliou presença de conteúdo anecóico dentro dos cornos uterinos, sugestivo de piometra. A paciente foi então encaminhada para o serviço de cirurgia para realização da ovariohisterectomia onde retirou-se o foco infeccioso. Na sequência, foi coletado material uterino, de forma estéril, para realização de cultura e antibiograma obtendo-se resultado positivo para dois tipos de bactéria, Streptococcus sp e Bastonete Gram negativo não fermentador. Foi prescrito no pós-operatório antibiótico, anti-inflamatório não esteroidal e analgésico, além de curativo diário, roupa cirúrgica e colar protetor. Não houve qualquer intercorrência no trans ou no pós-operatório da paciente, que não teve recidiva dos sinais clínicos, recebendo alta cirúrgica 10 dias após a cirurgia.

This study aimed to evaluate the clinical, epidemiological, and histopathological aspects of canine breast tumors at the Federal Rural University of Rio de Janeiro Veterinary Hospital (VH-UFRRJ) between April 2017 and October 2018. The study included 137 female canine dogs with mammary neoplasia who underwent a mastectomy. The animals were evaluated using a standard form that guided anamnesis and physical examination to assess the tumor’s epidemiology, development, evolution, treatment choice, and disease prognosis. Furthermore, laboratory and imaging tests were performed on the animals to search for changes that suggested metastasis. The average age of the female dogs was 10 years, and mixed-breed dogs (33%) were the most affected, followed by poodles (21%). The inguinal (79%) and caudal abdominal (64%) breasts were the most affected. Approximately 26% of the animals were castrated, 32% had already reproduced throughout their lives, 30% had pseudocyesis, and only 8% used contraceptive methods. The majority were classified as stage I (33%) and stage III (39%) according to the Tumor-Node-Metastasis (TNM) Classification System of Malignant Tumors. In 95 female dogs, 191 nodules were histopathologically evaluated, and 62% of these animals had at least one malignant tumor. Statistically, there was a direct association between tumor size and malignancy. However, other associations, such as age at diagnosis and the degree of malignancy, were not confirmed. Therefore, it can be concluded that tumor size is an important prognostic factor, with tumors >3 cm having an approximately 70% chance of being malignant.

Neuromuscular diseases are not common in clinical routine of dogs and cats and their diagnosis is a challenge for the veterinarian. This paper reports the clinical diagnosis and the therapy given to a four-year-old mixed-breed female dog with a history of claudication and intermittent paresis, initially in the pelvic limbs and then evolving to the thoracic limbs. Furthermore, there were clinical signs of ataxia and tetraparesis, especially after exercise. Due to the history and clinical signs presented, acquired myasthenia gravis was suspected and the therapeutic diagnosis using anticholinesterase neostigmine was chosen, as it is simple, fast and accessible. The dog presented a significant improvement in clinical status after intramuscular administration of the above mentioned anticholinesterase, and returned to normal ambulatory activity after administration of the drug intravenously, thus enabling the diagnosis of the disease. Treatment was introduced using pyridostigmine bromide (2.5mg/Kg, twice a day) associated with corticosteroid in an immunosuppressive dose (0.5mg/Kg, twice a day). Both drugs were administered orally for a period of six months, after which there was a complete remission of the clinical signs and there have been no recurrences until now.

This randomized clinical trial aimed to evaluate different fluid therapy protocols associated with inhalational or total intravenous anesthesia in the cardiorespiratory stability of bitches with sepsis subjected to a surgical procedure to control the infectious focus. Thirty-two bitches diagnosed with pyometra and sepsis and treated at the University Veterinary Hospital between 2018 and 2019 were recruited. After admission, diagnosis, clinical, and laboratory evaluation, patients were randomly distributed into the following groups: propofol 5 (P[5]: preoperative restrictive fluid therapy-5mL/kg/h and intravenous general anesthesia); propofol 10 (P[10]: preoperative liberal fluid therapy-10mL/kg/h and intravenous general anesthesia); and isoflurane 5 (I[5]: preoperative restrictive fluid therapy-5mL/kg/h and inhalational general anesthesia). Lactate on admission (LAC1) and release (LAC2), heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP), rectal temperature (RT), oxygen saturation (SpO 2 ), and carbon dioxide extraction rate (EtCO 2 ) were analyzed at PRE, T10, T20, T30, T40, T50, TEXT, and TDIS. Clearance of 20% of lactate occurred in 18 dogs, with the P[10] group displaying the best performance. There was no statistical difference in vasopressor requirements among the groups. Liberal fluid therapy showed greater cardiovascular stability than restrictive therapy in the perioperative period. Regarding general anesthesia, isoflurane showed greater cardiorespiratory stability than propofol during anesthetic maintenance. In conclusion, although the three proposed protocols are safe and there is no difference in their superiority, some observed changes may be relevant and considered when it is possible to individualize the therapy for the patient.

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