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A 58-year-old man who was very fond of eating raw fish and had not left Zaragoza Province in Spain in the last 20 years excreted a short chain of gravid proglottids. Treatment with 50 mg/kg of paromomycin sulfate was divided into three doses, all given within the same day, followed by administration of a laxative at night. On days 1 and 2 post-treatment, several chains of degenerated proglottids were evacuated. Only eggs were expelled on days 3 and 4. A long complete strobila including the scolex, and immature, mature, and gravid segments was spontaneously discharged on day 25 after treatment. It was identified as Diplogonoporus balaenopterae, and was the first confirmed case of diplogonoporiasis outside the Far East (all previous cases were reported from Japan, except for one recent case reported from Korea). The origin of this case, outside of its normal geographic location, may be associated with the importation of fish into Spain. The viability of the infective larval stage is evidence of its resistance to export/import conditions. Treatment with paromomycin sulfate did not result in the whole worm being discharged but several short strobilar chains showed drug-induced degeneration.

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Background: Craniopharyngioma is epithelial tumor located in the parasellar region, classified into histopathologically, genetically, clinically and prognostically as adamantinomatous and papillary subtypes Aim: A descriptive design, to determine the immunohistochemical expression of BRAFV600E, β-catenin, E-cadherin, clau1- 5, occludin, TNFα, IL6,10,20, gal-1,3,9 and Glut-3, 4, βFGF, IGF, EGFR, DPGF, Ki-67li and MVD in PaCPs. Materials and Methods: clinic, pathological immunostaining and ultrastructure correlation on paraffin embedded tissue sections of 13 cases of papillary craniopharyngioma. Results: Results. 10 (77%) male and 3 (23%) females, 8 (62%) recurrence and 5(39%) did not. 6 had a cystic appearance, 6 with atypia, 7 with squamous metaplastic changes with foamy macrophages and inflammation. Those who recurred presented higher indices of Ki67 and MVD, CK7, glut3, Gal3, Il6, Il20, and CD68 overexpression. BRAFv600E was doble immunofluorescence coexpresed with Il6, β-catenin, and TNFα as well as lower expression of E-cadherin, β-catenin, occludin, than those who did not recur. Likewise, by EM vacuole binding proteins, glycogen deposits and an increase in microgranules and loss of desmosomes observed. Opening or loss of intercellular adhesions. Pa CPs also presents paracrine secretion and probably lead to OMF production. Discussion: We observed a correlation with the expression of BRAFV600E with higher Ki-67Li and MVD, strong expression of growth factors, glucose transport galectins, inflammatory factor and loss of membranal TJ proteins expressed in epithelial cells. With they play an important role in cell polarity and cell adhesion, brain invasion as well as, in maintaining paracellular barrier functions, paracrine secretion and senesce.