Please cite this article as: Blake, M.G., Boccia, M.M., Krawczyk, M.C., Delorenzi, A., Baratti, C.M., Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation, Neurobiology of Learning and Memory (2012), doi: http://dx.doi. org/10.1016/j.nlm.2012.07.001 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. were not subjected to memory reactivation, suggesting that the performance effects are not due to non-specific effects of the drug. The effects of Ch also depended on the age of the reactivated memory. Altogether, our results suggest that Ch exerts its effects by modulating memory reconsolidation, and that the memory impairment induced by low doses of SCP is a memory expression failure and not a storage deficit. Therefore, reconsolidation, among other functions, might serve to change memory expression in later tests. Summarizing, our results open new avenues about the behavioral significance and the physiological functions of memory reconsolidation, providing new strategies for recovering memories from some types of amnesia.
Research highlights-Pre-training administration of scopolamine leads to memory impairment.-Intra-hippocampal administration of choline modulates memory reconsolidation -Choline reverses scopolamine-induced amnesia by enhancing memory reconsolidation -Low doses of scopolamine cause memory expression deficit, but not storage impairment -Reconsolidation could modify the ability of a memory for being expressed later
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