The aim of this study was to determine whether school-aged children born to mothers with gestational diabetes show delays in their neuropsychological development. Several key neuropsychological characteristics of 32 children aged 7 to 9 years born to mothers with gestational diabetes were examined by comparing their performance on cognitive tasks to that of 28 children aged 8 to 10 years whose mothers had glucose levels within normal limits during pregnancy. The gestational diabetes group showed low performance on graphic, spatial, and bimanual skills and a higher presence of soft neurologic signs. Lower scores for general intellectual level and the working memory index were also evident. Our results suggest that gestational diabetes is associated with mild cognitive impairment.

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We report the fifth female patient with Myhre syndrome (MS) and review the literature. She is a 13-year-old Mexican girl whose phenotype fulfills all the clinical and radiological criteria reported in MS such as typical facies, short stature, limited joint mobility, and short hands and feet. The physical habitus of MS is described and a square body shape is clearly distinguished in all cases. As the typical muscular build is present mainly in male patients, the MS muscular appearance may be hormonally influenced.

Ramírez‐Dueñas ML, Medina C, Ocampo‐Campos R, Rivera H. Severe Silver‐Russell syndrome and translocation (17;20)(q25;q13). Clin Genet 1992:41: 51–53. An 8‐year‐8‐month‐old girl with Silver‐Russell syndrome (SRS) and a paternally inherited balanced t(17;20)(q25;q13) is described. This observation suggests that an SRS gene(s) maps on chromosome 17 or 20 and that the patient phenotype resulted from either unmasking of heteroz‐ygosity or genomic imprinting via paternal disomy.

Garcia‐Cruz D, Figuera LE, Feria‐Velazco A, Sanchez‐Corona J, Garcia‐Cruz MO, Ramirez‐Dueñas RM, Hernandez‐Cordova A, Ruiz MX, Bitar‐Alatorre WE, Ramirez‐Dueñas ML, Cantu JM. The Myhre syndrome: report of two cases. Clin Genet 1993: 44: 203–207. © Munksgaard, 1993 Two unrelated patients, aged 19 and 6 years, were studied and diagnosed as having Myhre syndrome (MS). This review, together with three previous cases, permits further delineation of MS. The main features are: short stature, mental retardation, blepharophimosis, muscular hypertrophy, decreased joint mobility, thick calvarium, broad ribs, hypoplastic iliac wings and short tubular bones. Advanced paternal age at the propositi's birth suggests an autosomal dominant mutation as the cause of MS.