No abstract

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still mix up CKD with chronic kidney insufficiency or failure, For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus, health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is “solved” by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated aging and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal COVID-19 and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality which is 10- o 100-fold higher than similar age peers, and life expectancy is shortened by around 40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth global cause of death by 2040 and the second cause of death in Spain before the end of the century, a time when 1 in 4 Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded CIBER network research structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients (AAKP) and the European Kidney Health Alliance (EKHA). Leading Spanish kidney researchers grouped in the kidney collaborative research network REDINREN have now applied for the RICORS call of collaborative research in Spain with the support of the Spanish Society of Nephrology, ALCER and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true.

These cases probably represent a solid form of systemic EBV-positive T-cell lymphoproliferative disease of childhood, which requires identification and the development of appropriate therapy.

No abstract

En los ámbitos científicos existe un amplio acuerdo sobre la gran transición hoy en marcha hacia una sociedad planetaria, cuyo desenlace dependerá significativamente de cómo la humanidad logre resolver los graves conflictos sociales y del medio ambiente, de gravedad y magnitud anteriormente desconocidas. Actores del cambio en la dirección correcta son, entre otros, las universidades que cabe denominar en transición, cuyos pasos son cada vez más firmes en dirección a la sostenibilidad. En ellas, los factores que facilitan los procesos de cambio son numerosos y diversos, entre ellos, el compromiso institucional, una significativa clave del cambio institucional por la sostenibilidad. Este artículo aborda la cuestión situando el foco de atención en la Global Higher Education for Sustainability Partnership (GHESP) y sus cuatro integrantes: Association of University Leaders for Sustainable Future (USLF), Copernicus-Campus University Network for Sustainability, International Association of Universities y la United Nations University. Objetivo del estudio es constatar si sus Manifiestos y Declaraciones institucionales expresan explícitamente ese compromiso y, en su caso, los paralelismos que pudieran darse entre ellas en tres principales aspectos: la visión (imagen institucional), la misión que las universidades se atribuyen y las líneas estratégicas que recomiendan seguir a sus universidades miembros para cumplirla con eficacia. Los resultados ponen de manifiesto la estrecha afinidad entre los respectivos planteamientos así como el firme compromiso institucional con los principios y valores de la sostenibilidad. Un botón de muestra es la Conferencia de Rectores de las Universidades Españolas, miembro de una de las redes estudiadas

No abstract

El uso de drones en el periodismo permite la obtención de imágenes aéreas de difícil cobertura, con un consiguiente abaratamiento de costes, perspectiva, rapidez, movilidad y mayor seguridad para los periodistas. En este ensayo científico pretendemos analizar las oportunidades que brinda el uso de drones al relato informativo en España, con una industria incipiente, y debatir acerca de circunstancias que frenan su desarrollo para su incorporación a las rutinas periodísticas, como el coste que supone para los medios una inversión en una tecnología con una alta siniestralidad, escasa durabilidad y constante modernización, la complejidad técnica y administrativa que implica su uso, la escasez de periodistas especializados o las limitaciones de una legislación restrictiva, que hasta hace poco circunscribía la obtención de recursos gráficos a espacios rurales.

A biotinylated derivative of murine epidermal growth factor (EGF) was prepared by covalent attachment of the terminal amino group of EGF to N-biotinyl-epsilon-aminocaproyl-N-hydroxysuccinimide. The stoichiometry of biotin incorporation was in the range of one biotin moiety per EGF molecule. The biotinylated EGF (biotinyl-epsilon-caproyl-EGF, BioEGF) binds to EGF receptors on intact Ehrlich ascites carcinoma (EAC) cells with an affinity similar to that of native EGF and displays the same mitogenic activity as EGF in a soft agar test system with normal rat kidney (NRK) cells. BioEGF was visualized on cultured cells and tissue sections of a head and neck tumour by commercial streptavidin/avidin detection systems. Cytochemical analyses of certain tumour forms can be easily performed using the BioEGF probe.