Topical rhNGF is safe and more effective than vehicle in promoting healing of moderate-to-severe NK.

The observational phase was registered at Clinicaltrial.gov as NCT 02076763. The interventional phase study was registered at EudraCT as n° 2011-005590-23 and at Clinicaltrial.gov as NCT02082860.

No major transcriptional or phenotypic differences were observed in cultured HLECs derived from different regions of the limbus. However, explants of superior origin demonstrated the highest outgrowth success rate and generated epithelia with greater epithelial thickness and number of cell layers, which may prove useful for transplantation purposes.

This study is the first to verify the sterility of HLEC cultures prior to transplantation. Although a slight decrease in viability was observed following 2 weeks of storage, the HLEC sheets remain acceptable, whereas 3 week's storage was unsatisfactory.

ABSTRACT.Purpose: To test the feasibility of calculating neural contrast sensitivity function (neural CSF) from conventionally measured total contrast sensitivity function (total CSF) and measured modulation transfer function (MTF). Neural CSF considers the retina and the brain, whereas total CSF considers the optical eye media, the retina and the brain together. Methods: We studied three groups comprising nine eyes each: one group with normal ocular optics but retinal alterations (mild diabetic retinopathy), one with altered ocular optics and normal retina (keratoconus), and a normal control group. Results: Total CSF in the keratoconus and retinopathy groups was significantly lower compared to the control group. Modulation transfer function for keratoconus was lower, and in the retinopathy group was similar to that of the control group. Calculated neural CSF in the diabetes mellitus group was lower than in the control group whereas in the keratoconus group it was similar to that of the control group, with overestimations for some keratoconus cases. Conclusion: It is possible to calculate a meaningful neural CSF from measured total CSF and MTF data. The neural CSF represents a CSF adjusted for optical aberrations. This would allow comparison of the neural component of visual function in eyes with different optical aberrations.