Gram-negative bacilli (or Enterobacteriaceae) (E. coli, K. pneumoniae, P. aeruginosa, and Enterobacter cloacae) were the most common aerobic microbial isolates in bile cultures from patients with cholangitis in the Philippines. Their antimicrobial susceptibility patterns suggest that imipenem-cilastatin (sensitivity 100%), meropenem (100%), amikacin (90-100%), cefepime (75%-100%), ceftriaxone (75%-100%), gentamicin (67%-100%), and piperacillin-tazobactam (50%-100%) would be the most effective antimicrobials for both groups. However, the authors echo the caution from the Surgical Infection Society/Infectious Diseases Society of America against using aminoglycosides as empiric drugs when safer and equally effective regimens are available.
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