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ApreciseKUre is a multi-purpose digital platform facilitating data collection, integration and analysis for patients affected by Alkaptonuria (AKU), an ultra-rare autosomal recessive genetic disease. It includes genetic, biochemical, histopathological, clinical, therapeutic resources and quality of life scores that can be shared among registered researchers and clinicians in order to create a Precision Medicine Ecosystem (PME). The combination of machine learning application to analyse and re-interpret data available in the ApreciseKUre shows the potential direct benefits to achieve patient stratification and the consequent tailoring of care and treatments to a specific subgroup of patients. In this study, we have developed a tool able to investigate the most suitable treatment for AKU patients in accordance with their Quality of Life scores, which indicates changes in health status before/after the assumption of a specific class of drugs. This fact highlights the necessity of development of patient databases for rare diseases, like ApreciseKUre. We believe this is not limited to the study of AKU, but it represents a proof of principle study that could be applied to other rare diseases, allowing data management, analysis, and interpretation.

Abstract. The 1783 Scilla landslide–tsunami (Calabria, southern Italy) is a well-studied event that caused more than 1500 fatalities on the beaches close to the town. This paper complements a previous work that was based on numerical simulations and was focused on the very local effects of the tsunami in Scilla. In this study we extend the computational domain to cover a wider portion of western Calabria and northeastern Sicily, including the western side of the Straits of Messina. This investigation focuses on Capo Peloro area (the easternmost cape of Sicily), where the highest tsunami effects outside Scilla were reported. Important tsunami observations, such as the wave height reaching 6 m at Torre degli Inglesi and flooding that reached over 600 m inland, have been successfully modeled but only by means of a high-resolution (10 m) topo-bathymetric grid, since coarser grids were inadequate for the purpose. Interestingly, the inundation of the small lake of Pantano Piccolo could not be reproduced by using today's coastal morphology, since a coastal dune now acts as a barrier against tsunamis. Historical analysis suggests that this dune was not in place at the time of the tsunami occurred and that a ground depression extending from the lake to the northern coast is a remnant of an ancient channel that was used as a pathway in Roman times. The removal of such an obstacle and the remodeling of the coeval morphology allows the simulations to reproduce the tsunami penetration up to the lake, thus supporting the hypothesis that the 1783 tsunami entered the lake following the Roman channel track. A further result of this study is that the computed regional tsunami propagation pattern provides a useful hint for assessing tsunami hazards in the Straits of Messina area, which is one of the most exposed areas to tsunami threats in Italy and in the Mediterranean Sea overall.

Abstract. The 1783 Scilla tsunami, induced by a coastal landslide occurring during an intense seismic sequence in Calabria (South Italy), was one of the most lethal ever observed in Italy. It caused more than 1500 fatalities, most of which on the 10 beach close to the town where people gathered to escape earthquake shaking. In this paper, complementing a previous work (Zaniboni et al., 2016) focusing on the very local tsunami effects in the town of Scilla, we study the tsunami impact on the Calabria and Sicily coasts out of Scilla. To this purpose we take into account the same landslide geometry considered in the previous study and perform three tsunami simulations, one embracing a larger region with a 50-m computational grid, and two covering the specific area of Capo Peloro, in Sicily, facing Scilla on the western side of the Messina Straits, with even 15 higher resolution (10 m mesh). Numerical results show a very good agreement with the historical observations in Capo Peloro. Moreover, the resulting global tsunami inundation pattern provides a useful hint for tsunami hazard assessment in the Messina Straits area, which is known to be one of the most exposed to tsunami threat in Italy and in the Mediterranean Sea.

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Abstract. Eastern Sicily is affected by earthquakes and tsunamis of local and remote origin, which is known through numerous historical chronicles. Recent studies have put emphasis on the role of submarine landslides as the direct cause of the main local tsunamis, envisaging that earthquakes (in 1693 and 1908) did produce a tsunami, but also that they triggered mass failures that were able to generate an even larger tsunami. The debate is still open, and though no general consensus has been found among scientists so far, this research had the merit to attract attention on possible generation of tsunamis by landslides off Sicily. In this paper we investigate the tsunami potential of mass failures along one sector of the Hyblean-Malta Escarpment (HME). facing Augusta. The HME is the main offshore geological structure of the region running almost parallel to the coast, off eastern Sicily. Here, bottom morphology and slope steepness favour soil failures. In our work we study slope stability under seismic load along a number of HME transects by using the Minimun Lithostatic Deviation (MLD) method, which is based on the limit-equilibrium theory. The main goal is to identify sectors of the HME that could be unstable under the effect of realistic earthquakes. We estimate the possible landslide volume and use it as input for numerical codes to simulate the landslide motion and the consequent tsunami. This is an important step for the assessment of the tsunami hazard in eastern Sicily and for local tsunami mitigation policies. It is also important in view of tsunami warning system since it can help to identify the minimum earthquake magnitude capable of triggering destructive tsunamis induced by landslides, and therefore to set up appropriate knowledge-based criteria to launch alert to the population.

Geophysical surveys in the eastern slope of the Gela Basin (Strait of Sicily, central Mediterranean) contributed to the identification of several episodes of sediment mass transport, recorded by scars and deposits of various dimensions within the Pleistocene succession. In addition to a huge failure called Gela Slide with volume exceeding 600 km3, the most studied events show volumes estimated between 0.5 and 1.5 km3, which is common to many other submarine landslide deposits in this region and that can therefore be considered as a characteristic value. In this work, the tsunamigenic potential of two of such landslides, the so-called Northern Twin Slide and South Gela Basin Slide located about 50 km apart along the eastern slope of the Gela Basin, are investigated using numerical codes that describe the onset and motion of the slide, as well as the ensuing tsunami generation and propagation. The results provide the wave height of these tsunami events on the coast of southern Sicily and Malta and can be taken as representative of the tsunamigenic potential of typical landslides occurring along the slope of the Gela Basin.