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EditorPyoderma gangrenosum (PG) is an immune-mediated inflammatory condition characterized by ulcerative skin lesions. Management of this condition includes a combination of local wound care, topical and systemic therapy.A 64-year-old woman presented with a 1 month history of three painful ulcerations, on the distal part of both legs, two on the right (5 9 5 and 2.5 9 4 cm) and the other on the left (5 9 6 cm), with a depth ranging from 0.5 to 1 cm. Four years earlier she was diagnosed with ulcerative colitis, following treatment with azathioprine and remained asymptomatic. She had