Efficacy of carprofen, administered by different routes, was studied in experimental uveitis in dogs. Anterior chamber paracenteses was accomplished at two different moments (M0 and M1), with a five hour interval between them. At M0 and M1, 0.2mL of aqueous humor was collected and quantitation of total protein and prostaglandin E 2 (PGE 2 ) were determined. Four groups were formed (n=8), which received carprofen at the end of M0, by the following routes: subcutaneous (GIm), subconjunctival (GII), and topical (GIII). A fourth group that received no treatment was instituted (Control). Conjunctival histopathology of the GII animals was performed. In all groups, values of protein and PGE 2 significantly enhanced at M1; however, they did not significantly change among groups at M1. Inflammatory exudate of acute character and mild hemorrhage were seen at histopathology after carprofen administration. Carprofen was unable to inhibit PGE 2 synthesis and the protein influx to the anterior chamber by any of the tested routes. However, the reduction of 44% in protein levels (topical) suggests that the agent can be used by this route as an adjuvant to control uveitis in dogs.Keywords: dog, uveitis, carprofen, total protein, prostaglandin E 2 RESUMO Estudaram-se os efeitos do carprofeno, aplicado por diferentes vias, em uveítes experimentais em cães. Realizou-se paracentese de câmara anterior em dois momentos (M0 e M1), com intervalo de cinco horas entre si. Em M0 e M1, colheram-se 0,2mL de humor aquoso e determinaram-se as concentrações de proteína total e de prostaglandina E 2 (PGE 2 ). Constituíram-se quatro grupos (n = 8), que receberam carprofeno ao final de M0 pelas vias subcutânea (GI), subconjuntival (GII) e tópica (GIII). Um quarto grupo não recebeu tratamento (controle). Procedeu-se à avaliação histopatológica nos indivíduos do GII. Em todos os grupos
A four-year-old female entire Weimaraner, recently diagnosed with epilepsy, was referred with a three-week history of coughing and lethargy. The dog had been diagnosed with aspiration pneumonia on thoracic radiographs, but the cough continued despite antibiotic therapy and an apparent improvement in the radiographic lung changes. CT of the thorax revealed a diffuse and severe nodular thickening of the tracheal wall. Tracheoscopy showed a thickened and irregular mucosa with multiple nodules causing segmental stenosis of the trachea. Histopathology of the nodular tracheal mucosa demonstrated severe, multifocal to diffuse neutrophilic inflammation. Once infectious and neoplastic causes were excluded, the dog was diagnosed with an inflammatory tracheitis of unknown aetiology. A tapering course of glucocorticoids was prescribed, which led to a complete clinical and endoscopic resolution of the coughing and tracheal lesions, respectively.
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