Copper(I) mediated radical polymerisation is used to polymerise uridine and adenosine substituted methacrylates onto a silica surface giving supported polymers with potential as re-usable templates and for interaction with nucleic acids.

The preparation of immobilized poly(methacryloyl nucleosides) and their abilities for template polymerizations is discussed.

a b s t r a c tThe monomers methacryloyl uridine and methacryloyl adenosine have been polymerised under copper-mediated living radical conditions using poly(ethylene glycol) (PEG) macroinitiators to give triblock and pentablock copolymers of reasonable dispersity. The triblocks were used as initiators for the successful synthesis of pentablock copolymers. The secondary structures of the triblock and pentablock copolymers have been investigated using circular dichroism (CD) spectroscopy. The adenosine copolymers are found to exhibit more ordered secondary structures in water in comparison to the uridine derived polymers. New supramolecular structure is observed by CD upon mixing adenosine and uridine triblock copolymers in water. The polymers obtained are of interest as potential drug delivery agents through interaction with small molecules and oligonucelotides.