OBJECTIVES: To assess COVID-19 pandemic’s impact on adolescents’ sleep quality. METHODS: An anonymous online survey was conducted. Sociodemographic data and information about daily routine during and after lockdown were assessed. A descriptive statistical analysis was performed. RESULTS: In total, 258 participants, most female (71.7%) with median 15.7 years, were included. The quality of sleep during confinement was considered to be the same (58.1%) for those who normally classify their sleep as good or very good, but it was considered worse (83.3%) for those with usual bad or very bad sleep. Students delayed bedtime and wake up time during lockdown. Sleep habits before bedtime were equivalent during and after lockdown; however, in the latter, an increase in the use of videogames was reported. During lockdown, adolescents woke up less times during the night and got up easier in the morning. Once lockdown ceased and a normal routine restarted, 44.2% of the adolescents felt more productive during the day and 55.4% less anxious. DISCUSSION: School closure and home confinement during the COVID-19 pandemic impacted adolescents sleep. During lockdown adolescents delayed bedtime and wake-up time, sleep quality was worse in those who reported previous poor sleep quality, there was an increase in screen time use before bed. Nonetheless, it was easier for most of those inquired to wake up in the morning and they reported feeling less tired throughout the day. This result shows that the confinement allowed young people to adjust to the physiological phase delay of adolescence, decreasing daytime sleepiness.
Primary inherited epidermal growth factor receptor defects have recently been described in severe inflammatory skin disease and diarrhoea case reports. We describe two case reports of female preterm newborns of Roma consanguineous parents who presented both with alopecia and erythroderma/ichthyosis, in addition to nephromegaly at birth in case 1. Later, they both developed hypomagnesaemia and other severe hydroelectrolyte disturbances, recurrent life-threatening sepsis and failure to thrive. Exome sequencing identified a homozygous mutation in the epidermal growth factor receptor, rarely described. Despite optimization of medical supportive care, the prognosis was poor and both patients died before the first year of life. There are few similar cases of epidermal growth factor receptor homozygous mutation reported so far. Our manuscript describes the genetics, clinical presentation, and complex treatment of our two patients, aiming to contribute to new advances in the management of this condition.
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A soft tissue thoracic mass differential diagnosis includes congenital, inflammatory/infectious and neoplasic causes. A neoplasic aetiology - in which sarcoma is included - can be a challenging diagnosis, given its unpainful and slow growth nature. Despite being unusual, sarcoma must be considered in the presence of a gradually enlarging unpainful mass in the trunk or extremities, as this is the most common form of presentation. Quite often, the histologic exam of a soft tissue mass is essential for diagnosis and treatment planning.
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