Prospective observations over a ten-year period of 108 juvenile diabetics treated with unmeasured diet are reported. Description is given of the patient material, circumstances at diagnosis, and course of management. Hyperglycemia and glycosuria were common, and ketoacidosis occurred often. Total plasma lipidswere elevated. Chemical control was unsatisfactory according to current popular standards. Growth was less in those with onset before puberty, and the men were underweight. Infections may have been excessive. Adolescent emotional difficulties were exaggerated. Educational, athletic, and vocational achievements probably equaled the normal expectation. Pregnancies were only 55 per cent successful when fetuses were viable. The prevalence of degenerative complication was similar to that reported from restricted diet studies. No factors were found to account for vascular disease. It is surmised that the general course of the patients compared favorably to those reported to be following diets. It is also suggested that if diet control does have favorable effects, then those reported to follow diets are not following them, or factors other than control are more influential on the progression of juvenile diabetic vascular disease.

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Necrolytic acral erythema (NAE) is a relatively newly described dermatologic disease that is often associated with hepatitis C virus (HCV). Oral zinc therapy is a successful treatment; however, therapy is often delayed due to misdiagnosis. There are limited reports of NAE in the literature. This paper presents a case of NAE in a 68-year-old male with untreated HCV, whose NAE was diagnosed and treated as recurrent cellulitis for 12 years. He had low serum zinc and elevated serum glucagon levels. Elevated glucagon is not often reported in NAE, but the patient’s CT abdomen was negative, ruling out glucagonoma and necrolytic migratory erythema. He improved with oral zinc replacement and was referred to the hepatology department for HCV treatment. This paper additionally presents a review of the literature for NAE cases.

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Using the “3Cs” vaccine hesitancy framework which categorizes determinants of vaccine hesitancy across three dimensions—confidence, complacency, and convenience—we identify factors that shape COVID-19 vaccination intake and intention among Black and white residents in Southeast Michigan. We consider both historical discrimination in medicine and contemporary health and environmental crises (i.e., the Flint Water Crisis) as potential correlates. This study uses data from an online survey conducted between March–April 2021 in Flint and surrounding counties. we find that while historical mistreatment of Black people in healthcare and the Flint Water Crisis were of concern, those factors did not directly impact vaccination intention. Rather, concerns over safety, efficacy, and structural barriers related to access and occupation emerge as responsible for lower vaccination rates among Black residents. Effective vaccination programs require that public health authorities consider multiple factors, including the structural realities faced by racial ethnic minority groups which shape their vaccination decisions. Supplementary Information The online version contains supplementary material available at 10.1007/s10903-022-01401-0.