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SummaryAll the subjects in Northern Ireland who have been ascertained to suffer from Marian's syndrome or any incomplete form of this syndrome have been studied. A total of thirty‐one subjects in several generations have been ascertained and twenty‐six of these were living at the time of the survey. Twenty only are resident in Northern Ireland. Strict criteria of acceptance of the disorder have been postulated and it is probable therefore that mild (sporadic cases would be excluded even had they been notified.The literature on the clinical and hereditary aspects of Marfan's syndrome and the aetiology have been disoussed.

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