Aim Sudden unexplained nocturnal death syndrome (SUNDS) has been linked to the Brugada syndrome. In some places, acute haemorrhagic pancreatitis is widely held to cause it. We conducted a systematic, controlled autopsy study on Filipino SUNDS victims to rule out structural heart findings as well as acute haemorrhagic pancreatitis as causes. Methods and results A case control autopsy study was conducted comparing SUNDS victims between 18 and 50 years of age who died within 1 h of symptom onset with age-and gender-matched controls. There were 24 SUNDS (mean age 34.5 years) and 24 controls (mean 32.7 years). The autopsy incidence of structural heart disease was 8.3% (95% CI (1% to 27%)) and focal pancreatic haemorrhage was 4.17% (95% CI (0.1% to 20%)) but zero for true acute haemorrhagic pancreatitis among SUNDS victims. Autopsy findings in SUNDS versus controls were not significantly different from each other, showing no diagnostic abnormality in any of the organs. There was no significant difference in the incidence of acute haemorrhagic pancreatitis in both the SUNDS and control groups. We did not find fetal dispersion of the atrioventricular (AV) node, sclerosis or fibrosis of the AV conduction system, in a substudy of SUNDS cases. Conclusions We have shown that there is no significant difference in the overall autopsy findings between SUNDS and controls. Autopsy findings were normal in 70% of SUNDS; no cardiac structural pathology was found in 87% of cases. Haemorrhagic pancreatitis is the cause of death in a minority of SUNDS. The cardiac conduction system is normal in a subgroup of SUNDS studied.

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Funding Acknowledgements Type of funding sources: None. Introduction Post coronary artery bypass grafting (CABG), coronary angiography (CAG) is the gold standard for graft assessment to check the presence of occlusion or stenosis. Despite this, CAGs after a CABG in the nation are only conducted if patients show ischemic signs. Alternative to CAG, transit time flow measurement (TTFM) can be utilized to determine overall quality of blood flow in grafts. TTFM has yet been utilized to assess graft patency despite its availability in the nation. Purpose This study aims to provide TTFM profiles from CABG surgeries, including characterizing the differences in TTFM parameters between failed and normal grafts, as well as determining the association of TTFM parameters and related clinical factors to the likelihood of graft failure and major adverse cardiac events (MACE). Methods 279 patients were admitted to the cardiology centre from 1 January 2017 to 31 December 2019. Mann-Whitney test was used to compare the differences in TTFM parameters across different graft types, as well as between failed and normal grafts. To determine the likelihood of a graft being normal or failed based on established TTFM parameter cutoffs, χ² test was used. Lastly, multivariate logistic regression was used to determine the association between TTFM parameters and MACE, specifically angina, myocardial infarction, and death. Results Different graft types exhibited significant differences in TTFM parameters, particularly pulsatility index (PI) and diastolic filling (%DF). Arterial grafts presented with higher quality of blood flow compared to venous grafts, with left-sided grafts (especially LIMA-LAD) being the graft type of highest quality (Refer to Fig.1). However, there were no differences in TTFM parameters between failed and normal grafts (PI P = 0.893; DF% P = 0.143). Despite this, there was a greater number of failed grafts with PI > 5 (6.6%) compared to PI < 5 (2.6%) (χ²=4.021, P = 0.045). Multivariate analysis showed no significant association between TTFM parameters and prevalence of MACE. Instead, an increased risk of graft failure is associated with the female gender (P = 0.031), history of congestive heart failure (P = 0.025) and poor renal function (P = 0.034). Also, an increased risk of MACE is associated with a history of coronary intervention (P = 0.041), left coronary dominance (P = 0.018) and renal function (P = 0.009). Conclusion This study provides an overview of the TTFM profiles among different graft types used in CABG surgeries. While TTFM are not indicative of failed grafts upon ischemic signs, patient comorbidities were informative. Follow-up studies should include a larger sample size of patients from an earlier timeframe to assess correlation of graft failure over a 5-to-10-year span post-CABG. Regardless of ischemic signs, routine CAG for all patients should be considered to determine the true prevalence of graft failure among CABG patients in the nation. Abstract Figure. Fig1.Median comparison TTFM Parameters  Abstract Figure. Fig2. Multivariate analysis models