Natural sandalwood oil, a unique and valuable ingredient in fine perfumery, has been the focus of scientific interest for many years. Due to its scarcity and its high price, the search for novel synthetic raw materials imitating the characteristic odor profile of sandalwood oil is as challenging as ever. In this context, the preparation of the novel sandalwood odorants 26, 33, and 39 will be discussed, including their sensory properties and structure-odor relationship.
Communications
ADVANCED MATERIALSall of the CC1, was added to the working electrode side of the deposition cell. Current density for deposition was typically 2.5-5 mA/cm* and the galvanostatic depositions were carried out for 30-60 min.Scanning electron microscopy @EM) images were obtained using a Cambridge 360 SEM operating at 20 kV in secondary electron imaging mode. For the transmission electron microscopy (TEM) measurements, fibers were electrodeposited directly onto Cu mini grids. Bright field images and diffraction patterns were obtained using a Philips CM30 TEM operating at 300 kV accelerating voltage.X-ray photoelectron spectroscopic (XPS) measurements were made with a Perkin-Elmer model PHI 5100 spectrometer, using Mg-K, radiation. The X-rays were generated at 15 kV, 300 W, with the detector set at a take-off angle of 45". The sample was not sputtered prior to data collection.Raman spectroscopy was performed with a 488 nm laser (10 mW at the sample), and a single spectrograph (ISA 640) coupled to a 512 channel CCD detector (Photometrics PM512). A holographic band reject filter (Kaiser, OD = 6 at 488 nm) between the sample and spectrograph reduced elastic scatter. Integration times were 10-60 seconds, and no change in the spectrum was observed with repeated acquisition. 380" back-scattered geometry with a common focusing and collection lens was employed.
Musk odorants are one of the most important classes of fragrances in perfumery because they impart sensuality to perfume-oil compositions. Among the three well-known classes of musks, a new and very exciting generation of musk odorants, the so-called alicyclic musks, was discovered recently, of which Helvetolide (2) and Romandolide (3) are the most popular representatives so far. To find new, structurally related alicyclic musks, we have synthesized a library of 114 unique alicyclic molecules with modified cyclohexyl moieties. The olfactory properties of all compounds were evaluated to identify the structural requirements to be met for a musk odorant.
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