In the present study we investigated the involvement of free fatty acid (FFA) receptors in the anti-inflammatory role of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in dystrophic muscles, by administering FFA blockers in the mdx mouse model of dystrophy. Mdx mice (3 months-old) were treated with fish oil capsules (FDC Vitamins; 0.4 g EPA and 0.2 g DHA; gavage) alone or concomitant to FFA1 and FFA4 blockers (GW1100 and AH7614; i.p.). C57BL/10 mice (3 months-old) and untreated-mdx mice received mineral oil and were used as controls. After 1 month of treatment, plasma markers of myonecrosis (total and cardiac creatine kinase; CK), the levels of FFA1 and FFA4 and of the markers of inflammation, nuclear transcription factor kappa B (NFkB), tumor necrosis factor alpha (TNF-α) and interleukin 1β (IL-1β) were analyzed in the diaphragm muscle and heart by western blot. Fish oil significantly reduced total CK, cardiac CK and the levels of NFkB (diaphragm), and of TNF-α and IL-1β (diaphragm and heart) in mdx. In the dystrophic diaphragm, FFA1 was increased compared to normal.Blockers of FFA1 and FFA4 significantly inhibited the effects of fish oil treatment in both dystrophic muscles. The anti-inflammatory effects of fish oil in dystrophic diaphragm muscle and heart were mediated through FFA1 and FFA4.
Objective: to identify through the integrative review the importance of the implementation of the reception in Primary Health Care providing information about this attitude in the light of the published literature. Methodology: This is an integrative review of the literature, whose data were collected from secondary sources, through a bibliographic survey of scientific studies in Brazil, from 2017 to 2021, in three databases: VHL (Medical Literature Analysis and Retrieval System Online), Pubmed (U.S.National Library of Medicine) and Web of Science; the main question of the study was: What were the impacts on the quality of Primary Health Care with the implementation of reception in health services in Brazil in the last five years? Results: The search resulted in 160 articles, after reflective and critical reading of the abstracts, 15 articles were selected that met the objectives and the guide question, after the full reading of the articles was performed. Conclusion: Welcoming is a method designed to collaborate with the qualification of health issues, in a way that allows the user access to a fair and comprehensive care, through multiprofessionality and intersectoriality. It is a tool capable of enabling the SUS to effectiveness its constitutional principles. In addition, the study showed that welcoming promotes the connection of trust and commitment of users with the team and services, being a fundamental action for the humanization of the SUS and depends solely on the professionals inserted in the Primary Care network.
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