Modification of the St. John's wort acylphloroglucinol constituent, hyperforin (1), by acylation, alkylation, and oxidation resulted in detrimental effects on the inhibition of the synaptosomal accumulation of serotonin, showing the existence of definite structure-activity relationships in this in vitro test system and highlighting the role of the enolized cyclohexanedione moiety for activity on neurotransmitter reuptake.
Highlights
It simulates impact of COVID-19 on energy demand for a building mix at a district.
Confinement scenarios are proposed based on a new district design in Sweden.
Confinement measures increase electricity demand of buildings in the district.
Confinement measures reduce thermal energy demand of buildings in the district.
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