The aim of this review is to provide a general overview of the relationship between occupational stress and gastrointestinal alterations. The International Labour Organization suggests occupational health includes psychological aspects to achieve mental well-being. However, the definition of health risks for an occupation includes biological, chemical, physical and ergonomic factors but does not address psychological stress or other affective disorders. Nevertheless, multiple investigations have studied occupational stress and its physiological consequences, focusing on specific risk groups and occupations considered stressful. Among the physiological effects of stress, gastrointestinal tract (GIT) alterations are highly prevalent. The relationship between occupational stress and GIT diseases is evident in everyday clinical practice; however, the usual strategy is to attack the effects but not the root of the problem. That is, in clinics, occupational stress is recognized as a source of GIT problems, but employers do not ascribe it enough importance as a risk factor, in general, and for gastrointestinal health, in particular. The identification, stratification, measurement and evaluation of stress and its associated corrective strategies, particularly for occupational stress, are important topics to address in the near future to establish the basis for considering stress as an important risk factor in occupational health.© 2013 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Stress; Occupation; Gastric alterations; Gastrointestinal tract diseases; Health risks Core tip: In workers, the combination of personality patterns (anxiety/depression), stress and negative emotions contribute to gastrointestinal tract (GIT) alterations. In particular, jobs that produce privation, fatigue, chronic mental anxiety and a long past history of tension, frustration, resentment, psychological disturbance or emotional conflict have been shown to produce gastric ulcers. Irritable bowel syndrome and functional dyspepsia also have significant co-morbidity with mood alterations. Workers with unipolar depression have been shown to be more prone to present irritable bowel syndrome-like symptoms. Moreover, three systems are known to participate in the GIT alterations of workers: sympathetic autonomic nervous system, the hypothalamic-pituitary-adrenal axis and genetic factors.Huerta-Franco MR, Vargas-Luna M, Tienda P, DelgadilloHoltfort I, Balleza-Ordaz M, Flores-Hernandez C. Effects of occupational stress on the gastrointestinal tract. World J Gastrointest Pathophysiol 2013; 4(4): 108-118 Available from: URL:

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a b s t r a c t A set of calibration equations was previously obtained to transform the lung impedance changes obtained by electrical impedance tomography (EIT), using all frame's elements, into a measurable volume signal. In order to study the goodness of the use of regions of interest (ROI) for lung ventilation monitoring, we considered 6 different ROI to obtain a calibration equation for each area. Our aim was to compare the results, determined by these areas, and those obtained by using all EIT image elements. Two ROI's were defined by those pixels with an impedance change higher than 30% and 70% of the maximum change value. These areas were called P30 and P70, respectively. Two other ROI were defined by bounding two areas by mouse, resembling P30 and P70 regions, which were called M30 and M70, respectively. The remainder was defined by two elliptical areas with an eccentricity of 0.8, and 25 and 32 pixels of mayor axis (E25p and E32p, respectively). Twenty healthy males and 24 chronic obstructive pulmonary disease (COPD) patients were considered. For small region (P30 and M30) we obtained a large dispersion in volume measurement, concluding that small regions are not suitable for monitoring the tidal changes in lung volume even for healthy subjects. The results obtained by the remainder areas, and by using EIT image were similar. Even a slight improvement in data dispersion was obtained by using some ROI. These optimal results, for healthy people, were those corresponding to P70 and M70 (volume dispersion improved from 12% with the whole EIT image to 9% using ROI), and for COPD patients improves volume dispersion from 32% using the whole EIT image to 27% by using E25p. Using not so small ROI, it is possible to estimate the total lung ventilation. IntroductionIn clinical environment, there is nothing good enough to measure and monitor in a non-invasive manner the breathing pattern (BP), especially during large periods of time. The BP monitoring provides information about neuromuscular alterations suffered by patients and assesses organs that regulate breathing [1,2]. The reference method aimed to monitor the BP is the pneumotachometer. However, this device spontaneously modifies the behavior of respiration between 15% and 35% due to the essential use of a mouthpiece and clip-nose [3][4][5][6]. The pneumotachometer is mainly used in exercise stress testing in order to assess the pulmonary functional capacity during exercise. Other alternative method to monitor BP is the respiratory inductance plethysmography (RIP). This equipment is used to estimate lung volume by detecting respiratory movements of chest and abdominal wall. This method has been almost completely abandoned due to calibration problems [7][8][9]. Nowadays, this technique is used to monitor qualitatively respiration in patients with obstructive sleep apnea/hypopnea syndrome. A new experimental method used in clinical environment is the electrical impedance tomography (EIT). EIT is used to image regional impedance distribution in a cross-sectional...

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Extracts from submerged cultured mycelium of two strains of Flammulina velutipes, a popular culinary mushroom, were obtained by ultrasound and tested in vitro to determine their activity in innate immunity (monocytes/ macrophages). In addition, polyclonal antibodies against the extracts were produced. Both extracts have similar glycoproteins that contain mannose and glucose but have different glycoproteins with galactoseamine units. Two novel immunogenic glycoproteins with molecular weights of 32 and 25 kDa have been revealed. It is thought that these proteins are produced only by submerged cultured mycelium. Both extracts show immune-enhancing activity based on the significant modification of various parameters such as cytokine production, phagocytosis, and reactive oxygen species production.

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