Introduction and purpose: Celiac disease occurs in 1% of the general population. However, many cases remain unrecognized. The disease is a chronic immune-mediated disorder triggered by the ingestion of gluten that appears in individuals with genetic susceptibility. Celiac disease can develop in paediatric patients as well as adults. The purpose of this review is to analyze the newest information on the characteristics, diagnosis and treatment of patients with celiac disease. Material and methods: This review was based on available data collected in the PubMed database and published between 2015 and 2022. The research was done by looking through keywords such as: “celiac disease”, “Gluten-Free Diet”, “diagnosis” and “treatment”. Results: The diagnosis of celiac disease is most often delayed due to the broad spectrum of presentations. Screening of at-risk individuals is important to progress the diagnosis. It is additionally crucial to raise clinicians' attention to non-specific parenteral symptoms that may indicate celiac disease. The majority of the symptoms arise from nutritional deficiencies caused by intestinal malabsorption. According to scientific reports, the most common deficiencies of people with celiac disease are iron, folic acid, vitamin B12, fat-soluble vitamins and a calcium. Conclusions: Recent years have seen the emergence of research into new therapeutic options, but their efficacy and safety still need to be evaluated more thoroughly. Strict adherence to a gluten-free diet by patients is still the only treatment option at present. Celiac disease, due to the constant increase in knowledge about its pathogenesis, diagnosis and treatment is an important material for further research.
Introduction and objective: Psoriasis is a chronic inflammatory skin disease characterized by improperly differentiating epidermal keratinocytes. It may be associated with many coexisting diseases, mainly of the digestive, circulatory and autoimmune systems. Materials and methods: Pubmed database was searched. The criteria for qualifying the articl for the review were the following keywords: psoriasis, diet, sport, exercises, stress. 20 articles from 2017 to 2022 were analyzed. Description of the state of knowledge: Psoriasis has many links with metabolism, which depends on diet, exercise, and other diseases in the body. The excessive amount of pro-inflammatory substances can be regulated by supplying the body with anti-inflammatory ingredients in the diet as well as by physical activity that reduces the level of visceral fat. Many other diseases related to, inter alia, inflammation of the intestines or the state of the intestinal microbiota also affect the systemic distribution of cytokines and adipokines. An important factor influencing health is also mental stress and even epigenetic factors. Summary: Increased physical activity helps fight the main consequences of psoriasis. A similar effect is demonstrated by a low-calorie diet with a high content of anti-inflammatory ingredients and antioxidants and avoidance of pro-inflammatory substances. Treating other comorbidities and maintaining a low level of mental stress also have a positive effect on patients with psoriasis. All of the above interventions are effective complementary to pharmacological therapy.
Diabetes is the most common cause of CKD (chronic kidney disease). CKD is also one of the most important diabetic complication. SGLT2 (sodium glucose co‐transporter‐2) inhibitors are new class of medication used to lower high blood glucose level in people with type 2 diabetes. In new researches SGLT2 inhibitors demonstrated a significant and clinically relevant reduction in the risks of albuminuria and progression of nephropathy, doubling of serum creatinine levels, and initiation of renal replacement therapy. This review focuses on the therapeutic effectiveness of using SGLT2 inhibitors for the treatment of CKD in type 2 diabetes.
Introduction and purpose: Neonatal asphyxia is a medical condition in which the neonate is not able to maintain sufficient respiratory function. The hypoxia may be caused by either an impaired respiratory activity of the neonate or an interruption of blood flow to the placenta in the period immediately before or during delivery, which resulted in inadequate oxygen perfusion to vital organs. Description of the state of knowledge: Hypoxic-ischaemic encephalopathy (HIE) is a form of perinatal hypoxia, occurring in newborns after the 35th week of gestation and presenting along with neurological disorders. In fact, it is a major cause of death and infant disability. The incidence of HIE is approximately 2-5 per 1000 live births. The standard recommended treatment for perinatal hypoxic-ischaemic encephalopathy is therapeutic hypothermia. There are two methods used: selective head cooling with moderate whole-body hypothermia (SHC) and whole-body hypothermia (WBC). In both cases, metabolism and neural tissue destruction are slowed down. Conclusions: Therapeutic hypothermia is a promising treatment option for neonatal encephalopathy. Thus, it decreases the risk of death and neurological deficits in the form of cerebral palsy, epilepsy and psychomotor retardation. Whole-body hypothermia appears to be a more successful method than selective head cooling, however more research is still needed.
Introduction: The efforts to restore lost collagen, regain youthful-looking skin and healthier joints have made collagen oral supplements a huge trend of the last few years. Because collagen is the main building protein of our body, many people may ask themselves - can collagen supplementation have a real impact on our health? Are these nutraceuticals a fountain of youth in a bottle or nothing more than marketing hype?The aim of the study: The aim of this paper was to present the current state of knowledge on the supplementation of collagen and application of collagen in oral nutraceuticals. Material and methods: Literature review available on PubMed, Science Direct and Google Scholar and evaluation of available randomized controlled trials using collagen supplementation in terms of treatment effectiveness in terms of skin quality, anti-aging benefits and potential use in dermatology. Abstracts, comments, and non-English language articles were excluded. Conclusions: Collagen is important for maintaining the structural integrity of every tissue in the body. Despite many studies on collagen supplementation, the literature is still impecunious, but the scientific works so far confirm that supplementation with hydrolyzed collagen can improve various aspects of skin aging.Key words: collagen, collagen peptides, antiaging, skin health, nutraceuticals
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.