Aeroelastic optimization has become an indispensable component in the evaluation of divergence and flutter characteristics for plated/shell structures. The present paper intends to review the fundamental trends and dominant approaches in the optimal design of engineering constructions. A special attention is focused on the formulation of objective functions/functional and the definition of physical (material) variables, particularly in view of composite materials understood in the broader sense as not only multilayered laminates but also as sandwich structures, nanocomposites, functionally graded materials, and materials with piezoelectric actuators/sensors. Moreover, various original aspects of optimization problems of composite structures are demonstrated, discussed, and reviewed in depth.
The aim of the present paper is to describe and discuss on possible methods used in the divergence and flutter analysis of composite multilayered laminated structures. Dynamic instability is a very dangerous phenomenon and aeroelastic optimization has become an important element of the composite flight vehicle design process. A special attention is focused on the analysis of cylindrical panels and flat plates using numerical (finite element) methods. The structures with different flow angles, fibre orientations, stacking sequences and boundary condition are considered.
Concurrent measurements of serum TPA and PAP concentrations by double antibody radioimmunoassays were done in 49 patients with prostatic cancer in different clinical stages. The reference group comprised patients suffering from BPH. Positive TPA was found in 32.7% of cancer patients, the lowest percentage in stage A (11.1%) and the highest in stage D (55.6%). The additional value as a diagnostic aid of the TPA test was revealed on the basis of examination of the selected group of patients with not increased PAP. Positive TPA was found in 16.7% of patients: none in stage A, 22.2% in stage B, and 33.3% in stage D. Prostatic cancer remains the most common malignancy of the genitourinary tract. The improvement in the results of treatment involves not only a modernization of treatment modalities but also the introduction of laboratory tests which give the most ample information on the stage of tumour development and improve possibilities to control tumour therapy. Besides the refinement of the determination procedures of specific prostatic markers, prostatic acid phosphatase (PAP), through radio- and enzyme-immunological methods, there is a search for additional markers which might be helpful in diagnosis and follow-up of treatment.
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