Pituitary duplication is a rare malformation commonly associated with other major neural/craniofacial anomalies, easily shown by magnetic resonance imaging. The authors describe two girls with duplication of the pituitary gland and thickening of the hypothalamus, facial dysmorphism and precocious pubertal development. (2,6,8). Most of the cases are associated with other major neural/craniofacial anomalies which are easily shown by magnetic resonance imaging (MRI) and the majority of patients do not survive beyond infancy. Other pituitary hormone abnormalities are not usually present.The formation of the hypophysis depends on interaction of the embryonic primordium with normal growth processes in the prechordal region of the head. The prechordal plate and the rostral portion of the notochord are closely related to the development of the pituitary gland. The duplication of the rostral end of the notochord may act as the main factor that leads to duplication of the pituitary primordium, with resultant formation of two morphologically normal glands (8).The authors describe two girls with duplication of the pituitary gland and thickening of the hypothalamus, facial dysmorphism and precocious pubertal development.
apresentação de casos
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.