Justicia pectoralis (Acanthaceae) is used as an antiinflammatory, antimicrobial and bronchodilator, and its extract exerts an anxiolytic-like effect profile in animal models. This work presents the behavioral effects of an aqueous standardized extract of Justicia pectoralis (SEJP) in animal models, such as the elevated plus maze (EPM), light/dark, open field, rota rod and pentobarbital sleep time. The extract was administered intragastrically to male mice at single doses of 50, 100 and 200 mg/kg, while diazepam 1 or 2 mg/kg was used as a standard drug and flumazenil 2.5 mg/kg was used to evaluate the participation of benzodiazepinic receptors. The results showed that, similar to diazepam (1 mg/kg), SEJP significantly modified all the observed parameters in the EPM test, without altering the general motor activity in the open field, rota rod and pentobarbital sleep time tests. Flumazenil reversed not only the diazepam effect but also the SEJP effect. In the same way, all doses of SEJP increased the time of permanence in the light box in the light/dark test. The results showed that SEJP presented an anxiolytic-like effect, disproving sedative effects.
Bronchial stenosis can impair regional lung ventilation by causing abnormal,
asymmetric airflow limitation. Electrical impedance tomography (EIT) is an imaging
technique that allows the assessment of regional lung ventilation and therefore
complements the functional assessment of the lungs. We report the case of a patient
with left unilateral bronchial stenosis and a history of tuberculosis, in whom
regional lung ventilation was assessed by EIT. The EIT results were compared with
those obtained by ventilation/perfusion radionuclide imaging. The patient was using
nasal continuous positive airway pressure (CPAP) for the treatment of obstructive
sleep apnea syndrome. Therefore, we studied the effects of postural changes and of
the use of nasal CPAP. The EIT revealed heterogeneous distribution of regional lung
ventilation, the ventilation being higher in the right lung, and this distribution
was influenced by postural changes and CPAP use. The EIT assessment of regional lung
ventilation produced results similar to those obtained with the radionuclide imaging
technique and had the advantage of providing a dynamic evaluation without radiation
exposure.
Resumo
Objetivo Avaliar pacientes com fraturas intra-articulares de calcâneo tratados entre janeiro de 2015 e agosto de 2016 com técnica cirúrgica minimamente invasiva, com ênfase no resultado radiológico.
Métodos Estudo retrospectivo de 49 pacientes com 64 fraturas intra-articulares de calcâneo, submetidos a tratamento cirúrgico minimamente invasivo. As lesões foram tratadas com redução aberta por acesso mínimo lateral à articulação subtalar e fixação mínima. Foi realizado estudo radiográfico no pré- e no pós-operatório para aferição dos ângulos de Böhler e de Gissane.
Resultados O ângulo de Böhler médio dos casos antes da cirurgia foi de 2,5°, apresentando aumento da média dos ângulos para 25,3° após o tratamento cirúrgico minimamente invasivo. O ângulo de Gissane médio dos casos antes da cirurgia foi de 136,3°, apresentando diminuição da média dos ângulos para 114,3° na análise após a cirurgia.
Conclusão A técnica cirúrgica minimamente invasiva permite melhora dos parâmetros radiográficos (ângulos de Böhler e Gissane) nas fraturas intra-articulares de calcâneo, com sua adequada recuperação da forma anatômica.
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