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ObjectiveThe need for therapeutic options for muscle injuries, which are increasingly frequent among sports practitioners, was the motivation for this experimental study, which had the aim of evaluating the histological effects of platelet-rich plasma (PRP) on repairs to muscle tissues of rats.MethodsPRP was obtained by means of double centrifugation of blood from five animals. In 30 rats, an injury was produced in the middle third of the belly of the gastrocnemius muscle of each hind limb. These injuries did not receive any treatment in six rats (12 legs). In 24 rats, 0.9% physiological serum was injected into the injury in the left leg and PRP into the injury in the right leg. Samples from the treated and untreated tissue were evaluated histologically 7 and 21 days after the procedures.ResultsThe quantity of collagen in the injuries treated with PRP was significantly lower than that in the other injuries, in the evaluation made 7 days after the procedure, but it became equal to the other groups in the evaluation done on the 21st day. There was a significant increase (p < 0.001) in the quantity of collagen from the 7th to the 21st day in the injuries treated with PRP, but this was not seen in the injuries treated using other methods. The inflammatory process was shown to be more intense in the injuries treated with PRP than in the injuries of the other treatment groups, in the evaluation done 7 days after the procedure. However, the morphological aspects of these injuries were seen to be similar to those of the untreated injuries, 21 days after the procedure.ConclusionPRP promoted complete tissue restitution between the 7th and 21st days in experimental muscle injuries.

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All the authors declare that there is no potential conflict of interest referring to this article. Original articleActa Ortop Bras. 2010;18(6):349-52 ABSTRACTObjective: To evaluate clinical outcomes of the osteochondral autologous transplantation technique for treatment of osteochondral defects of the knee in athletes. Methods: For an average follow-up period of 52 months (30 to 82 months), 19 patients were evaluated pre and post-operatively by using subjective IKDC scores, modified Cincinnati Scores, and rate of return to sports activities. Prognosis according to age, duration of symptoms and location of the lesion was also evaluated. Results: Subjective IKDC scores were 64.6 + 6.8 pre-operatively and 81.8 + 20.1 post-operatively. Modified Cincinnati score was 5.3 + 0.8 preoperatively and 7.5 + 1.7 post-operatively. Fifty-three percent of the patients returned to pre-operative level of sports activity, 29% returned to a lower level, and 17% did not return to sports. Better results were observed in patients younger than 35 years, with less than one year of symptoms, in patients with femoral condyle defects and without concomitant meniscus or ACL tear. Throclear lesions had inferior results to condylar defects. Conclusion: Osteochondral autologous transplantation promoted a subjective improvement of the knee in athletes. Return to sports activity occurred in a specific group of patients