Background: A significant percentage of patients with pancreatitis often presents a history of excessive alcohol consumption. Nevertheless, the patho-physiological effect of ethanol on pancreatitis remains poorly understood. In the present study, we have investigated the early effects of acute ethanol exposure on CCK-8-evoked Ca 2+ signals in mouse pancreatic acinar cells. Changes in [Ca 2+ ] i and ROS production were analyzed employing fluorescence techniques after loading cells with fura-2 or CM-H 2 DCFDA, respectively.
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