532Cardona-Arias J, Peláez-Vanegas L, López-Saldarriaga J, et al. Introducción. El VIH/sida se considera una enfermedad crónica tratable dada la efectividad del tratamiento antirretroviral. En esta enfermedad es relevante evaluar aspectos que trascienden las medidas de presentación de la enfermedad; tal es el caso de la calidad de vida relacionada con la salud, que alude a los cambios que la enfermedad, los tratamientos y las discapacidades, producen en el estado funcional, las percepciones y las oportunidades sociales de las personas a lo largo de la vida. Objetivo. Describir la calidad de vida relacionada con la salud y su asociación con variables demográficas, socioeconómicas y clínicas, en adultos con VIH/sida de Medellín, 2009. Materiales y métodos. Se trata de un estudio transversal de 187 pacientes infectados. Se aplicaron el Medical Outcome Study Short Form (MOSSF36) y el World Health Organization Quality of Life (WHOQOL-BREF). El análisis se hizo con proporciones, medidas de resumen, intervalos de confianza, pruebas de t de Student, de U de Mann-Whitney y de Kruskal-Wallis, ANOVA y regresión lineal múltiple. Resultados. El 82,97 % de los enfermos usaba antirretrovirales, 74,66 % el cumplimiento del tratamiento fue superior al 95 %, y 74,68 % tenía recuento de linfocitos CD4 superiores a 200 células por mm 3 . Los puntajes de calidad de vida relacionada con la salud estuvieron entre 60,46 y 90,24. La presencia de enfermedad, la satisfacción con el apoyo familiar y con la situación económica, constituyeron los factores condicionantes más relevantes para la calidad de vida del grupo de estudio. Conclusión. En este grupo, la calidad de vida relacionada con la salud fue explicada por aspectos que trascienden el dominio biológico y se relacionan directamente con la dimensión económica y el apoyo social. ARTÍCULO ORIGINAL Calidad de vida relacionada con la salud en adultos con VIHPalabras clave: VIH, síndrome de inmunodeficiencia adquirida, calidad de vida, salud, Organización Mundial de la Salud, Colombia. Health related quality of life in adults with HIV/AIDS in ColombiaIntroduction. HIV/AIDS is now considered a chronic treatable disease because of the effectiveness of antiretroviral therapy. However, for this disease, issues require evaluation that goes beyond of disease occurrence. Health-related quality of life changes that may occur that continue throughout the life of the patient and may include functional status, perceptions of others, social opportunities, treatment requirements and disability. Objective. The health-related quality of life is to be characterized along with its association with demographic, socioeconomic and clinical conditions in adults with HIV/AIDS. Materials and methods. A cross-sectional study was conducted on a sample of 187 people with HIV/ AIDS in Medellín, 2009. The Medical Outcome Study Short Form (MOSSF36) and the World Health Organization Quality of Life (WHOQOL-BREF) were applied. The analysis was done with proportions, summary measures, confidence intervals, t Student, U...
Introduction: The human immunodeficiency virus (HIV) infection progressively destroys the immune system and increases the susceptibility to opportunistic infections. The aim of this study was to assess the benefits and safety of zinc supplements at nutritional doses. Methods: A randomized, double-blind, placebo control trial was performed in 40 adult patients that received either zinc sulfate or placebo daily during 12 weeks. The CD4 lymphocytes count was evaluated at the beginning and at the end of the intervention. Furthermore, we evaluated different clinical and epidemiological variables. Results: After the intervention, an increase ≥ 20% in CD4 lymphocytes was compared between groups; better response was observed in patients who received zinc (90% vs. 25%, p = 0.00), RR = 3.6 (95% CI 1.66; 7.8, p = 0.000) and reduction of relative risk of 74% compared to placebo. Conclusion: This clinical trial shows that patients who receive zinc sulfate supplement could increase the CD4 lymphocyte counting.
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