RESUMO
Álcool perílico (AP) é um monoterpeno com ação antitumoral comprovada, em estudos pré-clínicos
PALAVRAS-CHAVEGlioblastoma. Álcool perílico. Quimioterapia. Monoterpenos.
ABSTRACT
Intranasal delivery of anti-tumor agent perillyl alcohol: potential therapeutic alternative for patients with relapsed glioblastoma Perillyl alcohol (POH) is a monoterpene with preclinical antitumor activity in several types of tumor in rodent models and is currently under phase I and phase II clinical trials. Its proposed mechanism of action involves inhibition of post-translational isoprenylation of small G proteins, including p21-Ras
KEY WORDSGlioblastoma. Perillyl alcohol. Chemotherapy. Monoterpenes.
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