i a portable ice chest, the temperature of which varies from 5 to 8 C. It is immediately finished on its arrival and placed "i cold storage on the same day, the temperature of storage bung -15 C. As a rule, two weeks at least must elapse before sufficient purification takes place so that the virus jytll pass the bactériologie tests required by the Hygienic Laboratory. Potency tests arc then undertaken. This consists of a vaccination of children, and 100 per cent, of takes" is necessary to pass a virus. The period of time " cold storage before potency tests are made varies from •our to eight weeks. As soon as a potency test is completed, a return date of six months later is placed on this batch of virus (three months in summer) whether it is issued at '''is time or not. All viruses are retestcd every month.When issue is started, tests are made biweekly, and should they fail to give 100 per cent, of "takes," the virus is "«called. As the batch is issued, the date of the last test is stated; but the date of return remains the same for all of 'his batch, as stated above. All virus is kept in cold storage '•'I issued. We have nearly always on band parts of batches which have been in cold storage six months or more after the first potency tests. This, being continually tested, if 100 per cent. potent, is used locally in the department. We reserve 'he privilege of issuing such virus in emergencies, if we have !1 guarantee that it will be used promptly. Within the city hmits the distribution stations are controlled by inspection so that adequate refrigeration is maintained. Naturally we have no responsibility as regards vaccine virus purchased by others for distribution.1 think you will agree with me that the methods employed more than meet the demands of the Council and, with the buman potency tests, comprise as near an ideal system as can "e devised for the protection of the purchaser.In the regulations in their present form there are several Points which seem to me to leave opportunities for misunderstanding if not for actual fraud. For instance, "the date of killing of the bacteria shall be taken as the date of manufacture" (Section 3). Does not this leave a loophole by which bacterial suspensions could be placed in cold storage *'nd heated at any time thereafter, and this given as the tlate of killing?The intention of Section 4 is not clear to me. As I understand it, it seems to defeat the purpose of the preceding parar graphs. Does this mean that serums other than antitoxins 8nd bacterial vaccines can be placed in cold storage for .364 Jays after actual preparation or date.of bleeding and then ¡ssued with a new date (issue), implying that the latter date s the date of preparation or of bleeding? If so, I do not see how your regulations will improve present conditions. The same objection holds as regards the "date of manufacture" of vaccine virus. I agree that the potency will be maintained to a large extent under the conditions given, but why not qualify, for example, that the actual date of potency 'est within the...
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