Objectives. To evaluate the correlation between the psycho-emotional state and the pain factor in patients with oral lichen planus (OLP). Methodology. Patients (n = 287) with various verified clinical forms of OLP of the oral mucosa (OM) and patients of the control group (without OLP) (n = 32), matched by gender and age, were studied. The levels of anxiety and depression were studied according to the Beck method, the intensity of pain sensations on a visual analog scale using author's computer programs. Results. In the structure of the examined patients with OLP, the following clinical forms prevailed: typical form was 39.7% (n = 114), erosive-ulcerative – 31.0% (n = 89), exudative-hyperemic – 21.9% (n = 63 ), other forms – 7.4%, (n = 21). Analysis of the correlation between pain and anxiety (BAI) and depression (BDI) revealed positive mean correlations: r = 0.5627 (95% CI 0.4754–0.6390) and r = 0.4349 (95% CI 0, 3330–0.5268), at p < 0.0001, respectively. It is worth noting that the pain factor had a 29% greater influence on the state of anxiety than on the depression factor. Conclusion. In the complex therapy of OLP, it is necessary to take into account the psychological profile of patients, pain, understanding that these factors can be either initiating or supporting the pathological state. In view of this, the issue of an interdisciplinary approach and general planning of therapy with the involvement of specialized specialists is especially acute. The applied author's programs have shown convenience for both doctors and patients.
КОМПЛЕКСНОЕ ЛЕЧЕНИЕ ПЛОСКОЙ ФОРМЫ ЛЕЙКОПЛАКИИ СЛИЗИСТОЙ ОБОЛОЧКИ РТАГерасимова Л.П., Чемикосова Т.С., Вильданов М.Н. ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России, г. Уфа, Россия РезюмеЦелью настоящей статьи является оценка предложенного комплекса лечения плоской формы лейкоплакии слизистой оболочки рта в сравнении с традиционным методом. Методология проведения работы заключалась в следующем. Две группы пациентов получали лечение по поводу плоской формы лейкоплакии слизистой оболочки рта: первая группа (34 пациента) -получали традиционное лечение, вторая (30 пациентов) -предложенный комплекс лечения, включавший фотодинамическую терапию и коррекцию свободно-радикальных процессов ротовой жидкости. Результаты проведенной сравнительной оценки клинических результатов и показателей хемилюминесценции ротовой жидкости через 1,5 и 6 месяцев были следующими: отмечено достоверное снижение в обеих группах, но во II группе показатели были сопоставимы с показателями нормы; клинический анализ показал, что фотодинамическая терапия с гелем прополиса позволяет сократить сроки ликвидации гиперкератоза: в I группе пациентов (традиционное лечение) частичное клиническое выздоровление к концу срока лечения отмечалось у 11 (34,7 %) пациентов, полного клинического выздоровления не было отмечено ни у одного пациента; во II группе к концу срока лечения было отмечено полное клиническое выздоровление у всех пациентов.Отдаленные результаты параметров хемилюминесценции ротовой жидкости после фотодинамической терапии, в связи с полной элиминацией очагов лейкоплакии, были более стабильными и соответствовали значениям нормы.Таким образом, комплексное лечение плоской формы лейкоплакии с использованием фотодинамической терапии и геля прополиса вызывает нормализацию эпителиального слоя слизистой оболочки и является простым и эффективным методом. Ключевые слова: фотодинамическая терапия, лейкоплакия, свободно-радикальное окисление, хемилюминесценция, слизистая оболочка рта COMplex treatMent FOr hOMOgeneOUs Oral leUkOplakIa Gerasimova L.P., Chemikosova T.S., Vildanov M.N. Bashkir State Medical University, Ufa, Russia abstractObjectives An evaluation of the efficacy of the proposed complex treatment for homogenous oral leukoplakia in comparison with the standard method.Methods Two groups of patients were receiving treatment for homogenous oral leukoplakia: the first group (34 patients) received the standard treatment, while the second group (30 patients) underwent the proposed complex treatment, including photodynamic therapy and correction of free-radical processes in the oral fluid.Results The results of the comparative assessment of the clinical outcomes and indicators of oral fluid chemiluminescence after 1.5 and 6 months were as follows: a significant reduction in the disease indicators characterizing both groups was noted; however, the indicators of the second group were comparable with those of the normal range. A clinical analysis has shown that photodynamic therapy and application of a propolis gel reduces the...
Oral lichen planus is an inflammatory disease of the skin and oral mucosa, the etiology of which has not been fully elucidated, has a certain potential for malignancy and is often torpid to ongoing therapy. To evaluate the effectiveness and control of the therapy, we used a photo protocol using the author's computer program "OralPath – monitoring of pathological foci" (hereinafter referred to as the program). The aim of the study was to measure the area and fix localizations of erosions on the oral mucosa in patients with oral lichen planus using the author's computer program. Materials and methods. The areas of single and multiple erosions were recorded and measured in 89 patients with erosive form of oral lichen planus (47 men, 42 women), whose average age was 48,8±8,9 years. An analysis of groups for the normality of data distribution (Kolmogorov-Smirnov criterion, Shapiro-Vilka) was carried out. The groups were described using mean and standard deviation, and a 95% confidence interval was used to estimate the accuracy of the mean. Results of the study. The vast majority of erosions in oral lichen planus were of a single nature, and occurred in 80,9% of cases (n = 72). The area of erosions on the cheek mucosa was the largest in comparison with other localizations. With single lesions it was 1,92±0,7 cm2, with multiple lesions it was 2,6±0,63 cm2. The area of tongue erosions was 0,71±0,26 cm2 for single lesions and 1.08±0.19 cm2 for multiple lesions, respectively. Findings. The use of the computer program "OralPath – monitoring of pathological foci" in the practice of a dentist makes it possible to record observations of patients' conditions, evaluate the dynamics of changes in pathological foci, and, if necessary, correct the treatment process, as well as motivate patients.
BACKGROUND: The relevance of the study of oral lichen planus (OLP) does not raise doubts given the unclear etiological nature of this dermatitis, potential for malignancy, and difficulty in performing therapeutic measures. AIM: To assess the psychoemotional state of patients with various forms of OLP using a computer program (ConScale). MATERIAL AND METHODS: We examined 287 patients with a verified diagnosis of OLP. The average age of the patients was 47.89.0 years; men, 121 (42.1%); women, 166 (57.9%). RESULTS: Psychological parameters were assessed using ConScale according to the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI). In comparison with the control group (n=32) of comparable age and sex according to BAI and BDI, significant differences were found in patients with erosive-ulcerative, exudative-hyperemic, and bullous forms of LP. A relationship was found between these clinical forms of OLP and psychological conditions such as anxiety and depression. CONCLUSION: The results indicate the need to include psychological testing of patients with OLP in the protocol for a comprehensive assessment of the patients condition and treatment with individually selected sedatives.
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