THE JOURNAL OF UROLOGY® effects of GW427353 (i.v.) were evaluated on micturition reflex threshold, voiding efficiency, bladder pressure during bladder filling, MAP and HR in acetic acidevoked bladder irritation.RESULTS: GW427353 evoked concentration-dependent relaxations of isolated dog bladder strips (pD2 of 9.1 :!: 0.40; n = 14). In vivo, GW427353 evoked a maximal increase in micturition reflex threshold of 125 :!: 28 % and decreased bladder pressure during filling (21 :!: 2 %; 3 mg/kg i.v.). GW427353 had no effect on voiding efficiency or MAP, however HR was increased (108:!: 27%). CONCLUSIONS: The present studies demonstrate that stimulation of beta-3 adrenergic receptors with GW427353 evokes bladder relaxation and potentiates bladder storage mechanisms in the dog. The effects of GW427353 on HR are consistent with the species-selective role of beta-3 receptors in cardiovascular regulation in the dog (I). (I) Shen et al. (2004). JPET,
Perioperative parameters including time of surgery, estimated blood loss, need for blood transfusion, concomitant urologic procedure, time for return of bowel function, and length of hospital stay were examined. Clinical outcomes including early and late postoperative complications, and continence status were also analyzed.RESULTS: Median follow-up was 2.5 years (range 25 days to 5.6 years). Patients in the extraperitoneal group had significantly shorter operative time (3.9 hours vs. 5.6 hours, p< O.OOOl); shorter hospital stay (8.0 days versus 10.5 days, p=0.009); and shorter time to return to bowel function (3.5 days versus 4.9 days, p=0.0005). There was no significant difference in early or late complication rate. Postoperative continence was equally improved in both study groups. As expected, significantly more patients in the intraperitoneal group had prior abdominal surgery, 65% versus 29% (p=0.005), than those in the ex.traperitoneal group. When only patients with no prior abdominal surgery were compared (34 patients in the extraperitoneal group and 8 patients in the intraperitoneal group), the findings were analogous: shorter operative time, shorter length of stay, sooner return of bowel function, and no difference in complication rate.CONCLUSIONS: The extraperitoneal technique of augmentation enterocystoplasty provides an equally effective method of bladder augmentation to the standard technique with better postoperative outcomes.
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