No abstract

Ankle-joint sports injuries with poor rehabilitation results can seriously affect a patient’s quality of life. Nanobamboo charcoal has a strong adsorbability and disinfection effect. It has been used in ankle guards, but the effect of nanometer-sized bamboo charcoal has not been reported thus far. In this study, 98 patients with an ankle-joint motor injury were divided into a Regular Group and Joint Group (49 cases, each) using the random number table method. The Regular Group received the conventional treatment, and the Joint Group received nano-bamboo charcoal ankle guard combined with ankle-joint rehabilitation treatment. The analysis showed that ankle function, balance function, dorsiflexion range of motion, American Orthopedic Foot Ankle Society score, and total effective rate (91.84% vs. 73.47%) in the Joint Group were all higher than those in the Regular Group, while the Visual Analog Scale and Clinical Symptom Score scores were all lower than those of the conventional group (P < 0.05). This indicates that a nano-bamboo charcoal ankle guard combined with ankle-joint rehabilitation treatment can effectively reduce pain and improve ankle-joint balance, movement, dorsiflexion range of motion, and other functioning parameters of the patients, with a significant curative effect and high clinical application value.

In recent years, artificial intelligence technology has been widely used in various medical fields to effectively assist physicians in patient treatment operations. In this paper, we design and implement a deep biblical network model-based orthotic design for adolescent idiopathic scoliosis to quickly and effectively assist physicians in designing orthotics for adolescent idiopathic scoliosis. A fuzzy set is used to express the knowledge of adolescent idiopathic scoliosis orthosis design, and a fuzzy reasoning based on the confidence level is implemented. Finally, the efficiency of the design of adolescent idiopathic scoliosis orthoses was improved by 50% through two cases of adolescent idiopathic scoliosis patients, and the deviation rate between the inference value and the actual operation value of the domain experts was less than 10%.

Objection: To investigate whether Aloperine protects dopamine neurons in Parkinson's disease (PD) by activating autophagy and discuss its specific mechanism. Methods: C57BL/6 male mice were performed treated with MPTP (30 mg/kg) once daily for 7 d continuously to establish PD models. Dividing mice into Normal, Model, Alo and Alo+3-methyladenine (3-MA) groups. Aloperine (80 mg/kg) and Aloperine (80 mg/kg)+ 3-MA (2 mg/kg) were added into the mice of Alo and Alo+ 3-MA groups at the time of MPTP injection once daily. In the normal control group, sterile saline was injected into the abdomen simultaneously (30 ml/kg). Measuring apoptosis cell number by TUNEL assay, evaluating TH positive cell number, LAMP2A, α-Syn and LC3 including LC3-I and LC3-II proteins expression by IHC assay. Results: The apoptosis cell number of Model group was significantly increased (P < 0 05); Alo treatment, apoptosis cell number was significantly depressed (P < 0 05); while, the 3-MA supplement, the apoptosis cell number was significantly up-regulation (P < 0 05). Meanwhile, with Alo supplement, the relative protein including LAMP2A, -Syn, LC3-I and LC3-II proteins expressions were improved. Conclusion: Alo improved Parkinson's disease via regulation autophagy in vivo study.