The construction of bridges and other structures across the river will affect the flood discharge capacity and local water potential of the river.Based on navier-Stokes equation of MIKE21FM hydrodynamic module, this paper carries out two-dimensional numerical simulation of part of Shixi River. By optimizing the grid near the piers to reduce the difference brought by the terrain generalized grid of the real river, it simulates and analyzes the length of the curve of yong-high and Yong-water under different flood frequencies,the Nash-Sutcliffe efficiency coefficient and relative error analysis are used to verify the rationality of the results. The simulation results can accurately reflect the real changes of river water level, It provides a theoretical basis for flood impact analysis.