The COVID-19 pandemic created significant interest and demand for infection detection and monitoring solutions. In this paper, we propose a machine learning method to quickly detect COVID-19 using audio recordings made on consumer devices. The approach combines signal processing and noise removal methods with an ensemble of fine-tuned deep learning networks and enables COVID detection on coughs. We have also developed and deployed a mobile application that uses a symptoms checker together with voice, breath, and cough signals to detect COVID-19 infection. The application showed robust performance on both openly sourced datasets and the noisy data collected during beta testing by the end users.

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Interpretation of non-coding genomic variants is one of the most important challenges in human genetics. Machine learning methods have emerged recently as a powerful tool to solve this problem. State-of-the-art approaches allow prediction of transcriptional and epigenetic effects caused by non-coding mutations. However, these approaches require specific experimental data for training and can not generalize across cell types where required features were not experimentally measured. We show here that available epigenetic characteristics of human cell types are extremely sparse, limiting those approaches that rely on specific epigenetic input. We propose a new neural network architecture, DeepCT, which can learn complex interconnections of epigenetic features and infer unmeasured data from any available input. Furthermore, we show that DeepCT can learn cell type-specific properties, build biologically meaningful vector representations of cell types and utilize these representations to generate cell type-specific predictions of the effects of non-coding variations in the human genome.