This study aimed to investigate the relationship between red cell distribution width (RDW) and erythrocyte osmotic stability in non‐diabetic and diabetic individuals in both sexes. The study sample (N = 122) was constituted by 53 type 2 diabetics (DM) and 69 non‐diabetics (ND), being 21 and 22 men in each group, respectively. The osmotic stability of erythrocytes was obtained by the variation in saline concentration (dX) capable of determining hypoosmotic lysis. Higher RDW values and lower serum iron concentrations were found in the diabetic group when compared to the non‐diabetic volunteers. In the group of diabetic women, RDW was positively correlated with the reticulocyte index, and both RDW and dX were negatively correlated with iron, haemoglobin, transferrin saturation index, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration. In all the groups studied, RDW was positively correlated with dX, especially in the diabetic group, where the correlation was the strongest. RDW elevation in both women and men with type 2 diabetes mellitus was associated with decreased serum iron indicators. Furthermore, RDW has a similar meaning to dX, as small erythrocytes have less haemoglobin, resulting in both an increase of RDW and dX.

Caloric restriction (CR) reduces body weight and systemic inflammation, but effects on adipose tissue under dietary lipid overload are controversial. We evaluated the effects of CR-induced weight loss with a high-fat diet (HF) on adipose tissue inflammation of obese mice. Male mice were assigned into LF (low-fat diet) and HF. After 8-wk, HF was reassigned for another 7-wk into HF – kept at HF; LFAL - switched from HF to LF ad libitum; RHF - fed HF calorie-restricted to reach LFAL body weight. Serum markers, adipocytokines, morphology, and inflammatory infiltrates in retroperitoneal adipose tissue (RAT) were accessed. LFAL and RHF reduced body weights, equaling to LF. LFAL restored almost all inflammatory markers as LF, except tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and adiponectin. Compared to HF, RHF lowered visceral adiposity, retroperitoneal adipocyte sizes, RAT inflammatory cell infiltration as well as TNF-α, interleukin-6, hepatic and serum C-reactive protein, which were higher than LFAL; adiponectin and MCP-1 did not change. CR with high-fat diet reduced body weight and attenuated visceral adiposity, but did not fully recover visceral tissue inflammation. Novelty bullets • Caloric restriction in a high-fat diet ameliorated visceral adiposity. • Caloric restriction in a high-fat diet did not recover visceral adipose tissue inflammation.

With improvements in dental aesthetic requirements an increasing number of adults are seeking orthodontic treatment that, along with current lifestyle and eating habits of the adult population, makes orthodontists more likely to encounter patients with metabolic disorders such as diabetes mellitus. Speculated that the diabetic patient during orthodontic treatment may not experience a physiological healing process as a healthy patient. Therefore, the objective of this work is to present a current and contextualized review of the mechanisms by which uncontrolled diabetes mellitus impacts on bone remodeling and orthodontic tooth movement during the application of orthodontic forces. The following databases were searched MEDLINE (via PubMed), Scopus, Web of Science, SciELO, LILACS and open grey with these MeSH “bone remodeling”, “diabetes mellitus”, “orthodontic” and “tooth movement”. Five articles remained after search strategy and were analyzed. In sum, no clinical studies were found, the evidence was limited to animal studies (rats). The results suggest that there are differences in bone remodeling and tooth movement during the application of orthodontic forces in animals with diabetes mellitus when compared to healthy animals, especially when the disease is associated with periodontal disease. However, the results are still controversial and may be due to different study protocols.

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Introdução: A obesidade, considerada uma doença crônica não transmissível (DCNT), é responsável pelo surgimento de várias doenças no cenário epidemiológico do grupo das DCNTs. A cirurgia bariátrica, recomendada quando existe histórico de falha no uso de abordagens nutricionais, prática de exercício físico e uso de medicamentos, aparece como alternativa de tratamento para a redução do peso. Objetivo: Este estudo objetivou conhecer as características sociodemográficas de pacientes candidatos à cirurgia bariátrica em uma clínica privada, e, desse modo, traçar o perfil daqueles que utilizam e possuem acesso ao tratamento por esse tipo de serviço. Material e métodos: O estudo teve um delineamento transversal, com abordagem qualitativa e quantitativa, e foi realizada com voluntários que se apresentaram para a realização de cirurgia bariátrica em uma clínica particular especializada. A pesquisa foi aprovada pelo Comitê de Ética em Pesquisa com Seres Humanos da Universidade Federal de Uberlândia (CEP/UFU) com o registro CAAE: 23373019.0.0000.5152. Os resultados foram submetidos à análise estatística descritiva por frequência simples. A amostra do estudo consistiu em um total de 19 voluntários. Resultados: Desses 19 voluntários, 14 (73,68%) eram mulheres e 5 eram homens. A maioria dos voluntários se autodeclarou branca (63,16%), casada ou em união estável (63,16%), e 89,47% deles tinham filhos. O nível educacional predominante era o médio completo (42,1%). A maioria deles (94,74%) declarou ter rendimento mensal individual, sendo 52,63% com renda de 1 a 2 salários-mínimos. Conclusão: As dificuldades de acesso ao Sistema Único de Saúde (SUS), como a burocracia e a longa fila de espera, tornam a Rede de Saúde Suplementar a opção mais viável para aqueles que possuem melhores condições socioeconômicas e precisam recorrer à cirurgia bariátrica. Apesar da população coberta por esses planos de saúde ter aumentado nas últimas décadas, suas características sociodemográficas são muito específicas, principalmente em razão da etnia e renda, o que exclui a grande maioria da população.