Objective: To determine the relationship between mean arterial blood pressure (MAP) and blood viscosity in diabetic type 1 children and healthy controls to investigate whether MAP is independent of blood viscosity in healthy children, and vice versa.Research design and methods: Children with diabetes type 1 treated by insulin injection were studied. Controls were healthy children of both sexes. MAP was calculated from systolic and diastolic pressure measurements. Blood viscosity was determined indirectly by measuring blood hemoglobin (Hb) content. The relationship between Hb, hematocrit (Hct) and blood viscosity was determined in a subgroup of controls and diabetics selected at random.Results: 21 (10.6 ± 2.5 years) type 1 diabetic children treated with insulin and 25 healthy controls age 9.6 ± 1.7 years were studied. Hb was 13.8 ± 0.8 g/dl in normal children vs. 14.3 ± 0.9 g/dl in the diabetic group (p < 0.05). MAP was 71.4 ± 8.2 in the normal vs. 82.9 ± 7.2 mmHg in the diabetic group (p < 0.001). Glucose was 89.3 ± 10.6 vs. 202.4 ± 87.4 mg/dl respectively. Diabetics had a positive MAP/Hb correlation (p = 0.007), while normals showed a non significant (p = 0.2) negative correlation. The blood viscosity/Hb relationship was studied in a subgroup of 8 healthy controls and 8 diabetic type 1 children. There was no significant difference in Hb and Hct between groups. Diabetics showed a trend of increasing blood viscosity (+7%, p = 0.15).Conclusions: Normal children compensate for the increase in vascular resistance due to increased blood viscosity (increased Hb and Hct) while diabetic children do not, probably due to endothelial dysfunction.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.