Four unsaturated polyketide lactone derivatives, coibacins A-D, were isolated from a Panamanian marine
cyanobacterium, cf. Oscillatoria sp. The two different types of termini observed in these co-occurring metabolites, either a methyl cyclopropyl ring as seen in curacin A or a methyl vinyl chloride similar to that observed in the jamaicamides, suggest an intriguing flexibility in the “beta branch” forming biosynthetic process. The coibacins possess selective anti-leishmanial activity as well as potent anti-inflammatory activity.
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