A 30-year-old female from Yazd province, referred to the emergency department, with right lower quadrant (RLQ) pain. According to initial assessments and consulting with the general surgeon, the patient was hospitalized with the diagnosis of acute appendicitis and taken to the operating room for an open appendectomy. The appendix was inflamed and edematous with a minimal amount of pus discharge. It was excised without complications. Furthermore, the ovaries and terminal ileum were explored up to 60 cm. Post-operatively, the patient had a good general condition and normal abdominal examination. She
Isosexual precocious puberty in girls has several etiologies. Juvenile granulose cell tumor is one of the rarest causes that only stands for 1.5% of ovarian cancers. This tumor mostly encounters in first 2 decades of life. This paper is a report of an 8-year-old girl with precocious puberty that within five months developed breast enlargement followed by menarche. Works which are done to find the underlying cause of precocious puberty revealed juvenile granulosa cell tumor in her left ovary. She then under went laparoscopic surgery and 3 courses of chemotherapy. She did not experience any vaginal bleeding after that and the serum level of estradiol lay among its normal ranges, but after that the tumor relapsed and presented as abdominal pain and a huge mass which under went resection of all afflicted tissues. After 2 courses of chemotherapy, her status deteriorated and unfortunately she died after 6 months from the time of diagnosis. Treatment for this disease is consists of resection surgery and chemotherapy. If this tumor is diagnosed in its early stages, it will be curable, but in its advanced stages, up to 80% of patients die from recurrent tumors. The reported patient was diagnosed at stage IIIC that had poor prognosis.
Background and Aims: The Hepatitis C Virus (HCV) is essentially hepatotropic but virus compartment has also been found in other important extra hepatic sites. Detection of HCV RNA in extra hepatic reservoirs such as peripheral blood mononuclear cells (PBMCs) is important for determining of disease progression and effective treatment. The present study aimed to determine of different HCV genotypes in plasma and PBMCs specimens from patients of Yazd province of Iran. Materials and Methods: Blood samples of 50 patients with established HCV referred to Shahid Sadoughi Hospital were collected. These patients had positive anti-HCV and positive plasma HCV RNA. After RNA extraction from plasma and a pellet of approximately 3-5× 10 6 PBMCs, CDNA synthesis was done and stuck in-70°C. Then HCV genotyping by using of restriction fragment length polymorphisms (RFLPs) method was carried out. Finally, Data analysis was done by SPSS software. Results: The mean age of subjects infected with HCV 38/2±14/6 (ages 21-66) who were the majority of those between ages lower 30 years. 3a and 1a genotype distribution in plasma was significantly higher in those aged over 40 than other age that this difference in genotype distribution at the age of 40 is significant (P value> 0.04) but in PBMCs was not significant (p=0.25). 1a and 3a genotype distribution in plasma and PBMCs in between 40-30 ages showed a lower frequency than other ages. In none of the samples from patients with genotype 2 and 1b genotypes but only 3a and 1a such as mixed infections was detected. Typically, mixing virus infection in 8 patients (16%) in plasma and in 16 samples (32%) was identified in PBMCs. Conclusions: It suggested that plasma subtyping as the target genotype for considering of antiviral therapy is essential, but may be result to the goal of therapy. HCV genotyping in PBMCs samples along with plasma specimen might be beneficial. Therefore, determine of HCV genotype in PBMCs in before therapy because detection of occult infection is useful
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