Birthing ball is originally evolved in 1963 and its miles used as a physical remedy for the neurodevelopment remedy. It became delivered as a childbirth tool in 1980 through Perez and Simkin, Perez in 2001 said that the birthing ball turned into physically beneficial use in the course of pregnancy and labor by means of generating most advantageous positioning and pain discount at some stage in contraction whilst eliciting non-recurring motion. The size of population included this study was 80 GNM Nursing Final year students which were selected according to inclusive and exclusive criteria. The mean difference of 9.03 points in knowledge scoring between pre-test (7.65±1.21) and post-test (16.68±1.41) was statistically strongly significant (p<0.001). This is clearly reflected that the planned teaching programme regarding birthing ball exercise for promotion of normal birth of GNM Nursing final year students found to be effective in improving knowledge about birthing ball exercise for promotion of normal birth.
Unlike mammals, zebrafish possess a remarkable ability to regenerate damaged retina after an acute injury. Retina regeneration in zebrafish involves the induction of Müller glia-derived progenitor cells (MGPCs) exhibiting stem cell-like characteristics, which are capable of restoring all retinal cell-types. Here, we explored the importance of Phosphatase and tensin homolog (Pten), a dual-specificity phosphatase and tumor suppressor during retina regeneration. The Pten undergo rapid downregulation in the Müller glia and is absent in MGPCs, which is essential to trigger Akt-mediated cell proliferation to cause retina regeneration. We found that the forced downregulation of Pten accelerates MGPCs formation, while its overexpression restricts the regenerative response. We observed that Pten regulates the proliferation of MGPCs not only through Akt pathway but also by Mmp9/Notch signaling. Mmp9-activity is essential to induce the proliferation of MGPCs in the absence of Pten. Lastly, we show that Pten expression is fine-tuned through Mycb/histone deacetylase1 and Tgf-β signaling. The present study emphasizes on the stringent regulation of Pten and its crucial involvement during the zebrafish retina regeneration.
Promoting the health of the newborn and reduction of the neonate morbidity and mortality rate because now a day’s neonatal mortality and morbidity rates are continuously rising day by day so, that’s why it is important to conduct a pre-experimental study on Essential Newborn Care among Nursing student in selected College of Nursing Indore. The aim of the study is to assess the effectiveness of nurse led intervention. In this study 80 B.Sc. Nursing 3rd year student was selected by using Non probability convenient sampling techniques. Pre interventional knowledge level was assessed by Self-structured knowledge questionnaire. The data collected was analyzed by using descriptive and inferential statistics. The average (Mean ± Standard Deviation) knowledge scoring in pre-test to measure the pre-existed knowledge about essential new-born care found to be 6.89±1.32 points and the knowledge score at post-test stage found to be 19.13±2.00 points. The mean difference of 12.24 points in knowledge scoring between pre-test and post-test was statistically strongly significant (p<0.001) which clearly showed the effectiveness of nurse led module on knowledge of B. Sc. Nursing 3rd year students regarding essential new-born care. The positive mean difference of knowledge score shows that nurse led module was effective.
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